DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18233 and CG31013

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	171/539 - (31%)
Similarity:	286/539 - (53%)	Gaps:	59/539 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILVQSIHST-----DPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLD 71
            :||...|||     .|.:    |.:|.|::.:|.||::|::.:.|...|.|.|::|::.:...|.
  Fly     8 LLVMLFHSTLVLGHRPLE----KSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLL 68

  Fly    72 ALKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSAAPESFD 136
            .::..|.|.......::|||||.|.:||||:|||...:.|.::|:|:.||.|........|...|
  Fly    69 VIRAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPTERD 133

  Fly   137 MNEKLKAMHRIETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEAL 201
            :.:..:.:.||::||||:..|...|.:...::|..:...|.|::..:.|.......::.|.||..
  Fly   134 LWDACEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVP 198

  Fly   202 KLSTDGSLEIMNR---LKEIE-LKGFATAVAKRSIYLSNQGLTNETIDDMANS---QLQDAKLMD 259
            :...: .|.|..|   :||:: |:..|.|..|...|       :|.:..:.|.   |..||:::.
  Fly   199 QRLQE-ELLIQPRHLPIKEVDALRLLAEAQIKDQNY-------SEALPLLHNCLKLQPHDARVLR 255

  Fly   260 LEQLISSELKQWINDDSTTPPTDH-----------NLGCRGLFPKKSNLVCRYNSSTNAFLKLAP 313
            |.:    :...:|.:.....||::           .|.|.|.....:.|.|.||.:|..||:|||
  Fly   256 LWK----KTTDFIENQPDQSPTENKKRNVPIANAFKLSCNGPLESSTRLHCFYNFTTTPFLRLAP 316

  Fly   314 LKMEEISRDPYIVMFHEVISDKDIEEMKGEITE-MENGWTSLGDPKEI-------VSRVYWIRKE 370
            ||.|:|..|||:|::|||:|.::|..:.|:..: |:|  |.:...:.:       .::.:|::||
  Fly   317 LKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKN--TKIHKERAVPKKNRGRTAKGFWLKKE 379

  Fly   371 SS-FSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFY-------TDRLKEVDVNNTLG 427
            |: .:|||.:||.|||||.|.:....|:.|:|:||::..|.|::       ||......::  ||
  Fly   380 SNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSID--LG 442

  Fly   428 DRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWT 492
            |||.:::||..:|.|||.|||.|:...|.|:.|.|:||:|...|...|||:.|:.|||:|||:|.
  Fly   443 DRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWV 507

  Fly   493 ITKWLHYAPQLFVKPCSPR 511
            :|:|:....|:|::||.|:
  Fly   508 MTEWIREKRQIFIRPCLPK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	42/128 (33%)
		ATP-synt_B	<198..278	CDD:304375	19/86 (22%)
		P4Hc	333..498	CDD:214780	66/180 (37%)
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	42/128 (33%)
		TPR_11	178..248	CDD:290150	16/77 (21%)
		TPR repeat	211..246	CDD:276809	9/41 (22%)
		P4Hc	336..513	CDD:214780	66/180 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461796
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910