Protein Alignment CG18233 and P4HA3

DIOPT Version :10

• Sequence 1: NP_649044.3
• Gene: CG18233 / 40025
• FlyBaseID: FBgn0036795
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 128/582 - (21%)
• Similarity: 248/582 - (42%)
• Gaps: 105/582 - (18%)

  Fly     9 AVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDAL 73
            |.|:.|.::.:.||.....|....|::..:.:.|..|:..:.....|....:.::.:|..|.|.:
Human     8 AALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDKV 72

  Fly    74 KRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQD----IVSAAPES 134
            .    ..|.:....|:|||.||.||:||..||   :|........|.:.|::|    :....|..
Human    73 L----SLHEDSTTPVANPLLAFTLIKRLQSDW---RNVVHSLEASENIRALKDGYEKVEQDLPAF 130

  Fly   135 FDMNEKLKAMHRIETTYDLQPKDIAKGLLQRTE-------FNYRLLFR----DCLALAYHKFEIG 188
            .|:....:|:.|::..|.|..|.:|:|:.||..       ::.:.||.    ||..:....:::|
Human   131 EDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMG 195

  Fly   189 EFKRSLLWFQEALKL--------STDGSLEIMNRLKEIELKGFATAVAKRSIYLSNQGLTNETID 245
            ::..::.|.:||:.|        .|:....:.:.|..:....|.......::.||.:.|.....:
Human   196 DYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDN 260

  Fly   246 D-MANSQLQDAKLMD-------LEQLISSELKQWINDDSTTPPTDHNLGCRGLFPKKSNLVCRYN 302
            . ||.:.|:..:|:.       .|.:|.......:....|.......||.:....:..:|.|.|.
Human   261 KRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYE 325

  Fly   303 SSTNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITE--MENGWTSLGDPKEI----- 360
            :::||:|.|.|::.|.|..:|||.::|:.:||.:.:::: |:.|  ::....:.|: |::
Human   326 TNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIR-ELAEPWLQRSVVASGE-KQLQVEYR 388

  Fly   361 VSRVYWIRKESSFSK--RINQRISDMTGFKLE----EFPAIQLANFGVGGYFKPHYDFYTD---- 415
            :|:..|: |::...|  .:|.||:.:||..:.    |:  :|:.|:|:||:::||:|..|.
Human   389 ISKSAWL-KDTVDPKLVTLNHRIAALTGLDVRPPYAEY--LQVVNYGIGGHYEPHFDHATSPSSP 450

  Fly   416 --RLKEVDVNNTLGDRIGSIIFYAGEVSQGGQT--VFPDLKVAVEPK----------KGN----- 461
              |:|.       |:|:.:.:.|...|..||.|  ::.:|.|.|...          ||.
Human   451 LYRMKS-------GNRVATFMIYLSSVEAGGATAFIYANLSVPVVRHCFGGTCTGVVKGTVTHFM 508

  Fly   462 --ALFW----------FNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQLFVKPCSPR 511
              .|.|          :.:.|.::.||.:......:|....|       ::|..|.:...|:
Human   509 LAVLSWWEISGWPTSGYMSMDRNSADPAAPALKTELLAERSW-------WSPVAFQRSQEPK 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..164	CDD:462433	32/133 (24%)
		P4Hc	333..498	CDD:214780	46/212 (22%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433	29/108 (27%)
		BepA	<188..289	CDD:443813	17/100 (17%)
		P4Hc	356..>478	CDD:214780	34/133 (26%)