DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18233 and P4ha2

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_006532515.1	Gene:	P4ha2 / 18452	MGIID:	894286	Length:	557	Species:	Mus musculus

Alignment Length:	573	Identity:	154/573 - (26%)
Similarity:	273/573 - (47%)	Gaps:	100/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLILVQSIHSTDPNDFLNRKYYSSSVLG-LVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDAL 73
            ||:||..:.......::..::::|  :| :..|:..|::.:.:...|..:.:.|:..:..:...:
Mouse     5 VLVLVLLMSWFGVLSWVQAEFFTS--IGHMTDLIYAEKDLVQSLKEYILVEEAKLAKIKSWASKM 67

  Fly    74 KRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSAA------- 131
            :....::..:.|.::::|:||:.|::|||.|||.|.:           ..:|| .||.
Mouse    68 EALTSRSAADPEGYLAHPVNAYKLVKRLNTDWPALGD-----------LVLQD-ASAGFVANLSV 120

  Fly   132 -----PESFDMNEKLKAMHRIETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFK 191
                 |...|.:...:|:.|::.||.|.|..|::|.|..|::...|...||..|....:..|::.
Mouse   121 QRQFFPTDEDESGAARALMRLQDTYKLDPDTISRGELPGTKYQAMLSVDDCFGLGRSAYNEGDYY 185

  Fly   192 RSLLWFQEALKLSTDGSLEIMNRLKEIELKGFATAVAK-----RSIYLSNQGLTNETIDDMANSQ 251
            .::||.::.||....|  |.....|.:.|...:.||.:     |::.|:.:.|:.:...:.|...
Mouse   186 HTVLWMEQVLKQLDAG--EEATVTKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGN 248

  Fly   252 LQDAKLMDLEQLISSELKQWINDDSTT----------PPTDH--------NLGCRG----LFPKK 294
            |:     ..|:|:..|..:.:::.:..          .|||:        :| |||    |.|::
Mouse   249 LR-----YFERLLEEERGKSLSNQTDAGLATQENLYERPTDYLPERDVYESL-CRGEGVKLTPRR 307

  Fly   295 -SNLVCRYNSSTNA-FLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDP 357
             ..|.|||:..... .|.:||.|.|:....|:||.:::|:||::||.:| ||.:.:....::.||
Mouse   308 QKKLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIK-EIAKPKLARATVRDP 371

  Fly   358 KE--------IVSRVYWIRKESS-FSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDF- 412
            |.        .||:..|:.::.. ...|:|:|:..:||..::....:|:||:|:||.::||:||
Mouse   372 KTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFS 436

  Fly   413 --------------------YTDRLKEVDVNNTL--GDRIGSIIFYAGEVSQGGQTVFPDLKVAV 455
                                |:|   |.|....|  |:|:.:.:.|..:|..||.||||||..|:
Mouse   437 RRPFDSGLKTEGNRLATFLNYSD---EQDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAI 498

  Fly   456 EPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQLFVKPC 508
            .||||.|:||:|.......|.|:.|:.||||||.:|...||.|...|.|::||
Mouse   499 WPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	31/141 (22%)
		ATP-synt_B	<198..278	CDD:304375	16/84 (19%)
		P4Hc	333..498	CDD:214780	66/196 (34%)
P4ha2	XP_006532515.1	P4Ha_N	28..157	CDD:369820	32/142 (23%)
P4ha2	XP_006532515.1	P4Hc	348..541	CDD:214780	66/196 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920