Protein Alignment CG18233 and dpy-18

DIOPT Version :10

• Sequence 1: NP_649044.3
• Gene: CG18233 / 40025
• FlyBaseID: FBgn0036795
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_499464.1
• Gene: dpy-18 / 176569
• WormBaseID: WBGene00001077
• Length: 559
• Species: Caenorhabditis elegans
• Alignment Length: 534
• Identity: 140/534 - (26%)
• Similarity: 244/534 - (45%)
• Gaps: 90/534 - (16%)

  Fly    33 SSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNEREKFVSNPLNAFGL 97
            :|:..:..||:.|:........|.:..:|::..|....:...:.|..:.....|.::||:|||.|
 Worm    20 TSIADMQNLLETERNIPKILDKYIHDEEERLVQLKKLSEEYSKKNEISIENGLKDITNPINAFLL 84

  Fly    98 IRRLNQDWPKLQNYTQKPLGLEQLTAMQ--DIVSAA---------PESFDMNEKLKAMHRIETTY 151
            |:|...||.::::         ::.|.:  ::||:.         |.:.|::.....:.|::.||
 Worm    85 IKRKIFDWKEIES---------KMNANKAGNVVSSITDDSYGVRYPTADDLSGAAIGLLRLQDTY 140

  Fly   152 DLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALKLSTDGSLEIMNRLK 216
            .|..||:|.|.:...:.||....:||..:|...:...:|..:::|.:||.:...| .:|....::
 Worm   141 RLDTKDLADGKIYADQGNYTFSAKDCFEIARAAYNEHDFYHTVMWMEEAQRRLGD-EVEPTVEVE 204

  Fly   217 EIELKGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAK--------LMDLEQLISSELKQWIN 273
            :| |:..|.|:.|::.......||.|..  ..|.....||        |::.|.:..|::::
 Worm   205 DI-LEYLAFALYKQNNLKHALKLTEELY--KMNPTHPRAKGNVKWYEDLLEQEGVRRSDMRK--- 263

  Fly   274 DDSTTPP-----TDHNLG----------CRGLFPKK----SNLVCRYNSSTNAFLKLAPLKMEEI 319
               ..||     .|..||          ||...|..    |.|.|.|... ..||..||:|:|..
 Worm   264 ---NLPPIQNRRPDSVLGNTERTMYEALCRNEVPVSQKDISRLYCYYKRD-RPFLVYAPIKVEIK 324

  Fly   320 SRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDPK------------EIVSRVY------W 366
            ..:|..|:|.:||||.::..::           .|..||            ::|:..|      |
 Worm   325 RFNPLAVLFKDVISDDEVAAIQ-----------ELAKPKLARATVHDSVTGKLVTATYRISKSAW 378

  Fly   367 IRK-ESSFSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDF-YTDRLKEVDVNNTLGDR 429
            ::: |....:.:|:||..||..::|....:|:||:|:||::.||:|. ..:..|..:...| |:|
 Worm   379 LKEWEGDVVETVNKRIGYMTNLEMETAEELQIANYGIGGHYDPHFDHAKKEESKSFESLGT-GNR 442

  Fly   430 IGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTIT 494
            |.:::||..:.|.||.|||.:.|..:.|.|.:||||:|.:.....:|.:.|:.||||||.:|...
 Worm   443 IATVLFYMSQPSHGGGTVFTEAKSTILPTKNDALFWYNLYKQGDGNPDTRHAACPVLVGIKWVSN 507

  Fly   495 KWLHYAPQLFVKPC 508
            ||:|.....|.:||
 Worm   508 KWIHEKGNEFRRPC 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..164	CDD:462433	32/140 (23%)
		P4Hc	333..498	CDD:214780	56/184 (30%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:462433	32/139 (23%)
		NrfG	150..>240	CDD:443378	21/93 (23%)
		P4Hc	338..511	CDD:214780	56/184 (30%)