DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18233 and p4ha1

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	527	Identity:	142/527 - (26%)
Similarity:	246/527 - (46%)	Gaps:	73/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNEREKFVSNPLNAF 95
            :.:|:..::.||..|::.:.:...|....::|:..:..:.|.|.........:.|.::.:|:|||
Frog    20 FFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTATKDPEGYLGHPVNAF 84

  Fly    96 GLIRRLNQDWPKLQNYTQKPLG---LEQLTAMQDIVSAAPESFDMNEKLKAMHRIETTYDLQPKD 157
            .|::|||.:|.||:|...|.:.   :..||..:...   |...|.....||:.|::.||:|....
Frog    85 KLMKRLNTEWVKLENLILKDISDGFISNLTIQRQYF---PNDEDQTGAAKALLRLQDTYNLDTDT 146

  Fly   158 IAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALKLSTDGSLEIMNRLKEIELKG 222
            |:||.|...:....|...||..|....:...::..:.||.::||.....|....::::..::...
Frog   147 ISKGNLPGVKHKTSLTAEDCFDLGKTAYTDADYYHTELWMEQALSQLDAGEESSLDKVMVLDYLS 211

  Fly   223 FAT----------AVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDLEQLISSELKQWINDDST 277
            :|.          .:.|||:.|..:       ....|.        :|..::|.|    .|..|:
Frog   212 YAVYQQGDLDKALTLTKRSLELDPE-------HQRGNG--------NLRHIMSKE----SNKSSS 257

  Fly   278 TP------------PTDH------NLGCRG-----LFPKKSNLVCRY-NSSTNAFLKLAPLKMEE 318
            :|            |.||      ...|||     ...::..|.||| :...:..|.|:|.|.|:
Frog   258 SPSEGAELRTRKGRPKDHLEKEKYEKLCRGEGVKMTSRRQKRLFCRYFDGKKDPLLILSPTKQED 322

  Fly   319 ISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDP--------KEIVSRVYWIR-KESSFS 374
            ....|.||.:|::|||::|.::| |:.:......::.:|        :..:::..|:. .|....
Frog   323 EWDKPRIVRYHDIISDEEISKVK-ELAKPRLRRATISNPITGVLETAQYRITKSAWLSGYEDPVV 386

  Fly   375 KRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDVNNTL--GDRIGSIIFYA 437
            .|:|:||..:||..:.....:|:||:|:||.::||:||.  |..|.|....|  |:|:.:.:||.
Frog   387 ARLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDFL--RKYEPDAFKKLGTGNRVATWLFYM 449

  Fly   438 GEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQ 502
            .:|..||.||||::..||.||||.|:||:|..:....|..:.|:.||||||::|...||:|...|
Frog   450 SDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVGNKWVSNKWIHERGQ 514

  Fly   503 LFVKPCS 509
            .|.:||:
Frog   515 EFRRPCN 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	35/131 (27%)
		ATP-synt_B	<198..278	CDD:304375	14/89 (16%)
		P4Hc	333..498	CDD:214780	60/175 (34%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	21/86 (24%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	60/175 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110