DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18233 and p4ha1b

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_999856.1	Gene:	p4ha1b / 100003675	ZFINID:	ZDB-GENE-030131-4089	Length:	536	Species:	Danio rerio

Alignment Length:	525	Identity:	155/525 - (29%)
Similarity:	254/525 - (48%)	Gaps:	50/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNEREKF 87
            |||.      :|...:..||..|::.:.:...|....:.:::.:..:.|.|.........:.|.|
Zfish    19 NDFF------TSTGQMTDLLYAEKDLVTSLKEYIKQEENRLEQVKEWADKLDSLTITATQDPEGF 77

  Fly    88 VSNPLNAFGLIRRLNQDWPKLQNYTQKPLG---LEQLTAMQDIVSAAPESFDMNEKLKAMHRIET 149
            :.:|:|||.|::|||.:|..|:|...|...   :..||..:...   |...|.....||:.|::.
Zfish    78 LGHPVNAFKLMKRLNSEWSDLENLVLKDTTNGFISNLTVQRQYF---PTDEDQTGAAKALLRLQD 139

  Fly   150 TYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALKLSTDGSLEIMNR 214
            ||.|....|:.|.|.......|:...||..|....:...::..:.||..:||....:|....:::
Zfish   140 TYQLSANAISSGDLPGVVHKSRMTVEDCYELGKIAYSDADYYHTELWMAQALSQLDEGEESPIDK 204

  Fly   215 LKEIELKGFA---TAVAKRSIYLSNQGLTNETIDDMANSQLQ--------------DAKLMDLEQ 262
            :..::...:|   .....|::.|:.:.|..:.....||..|:              :.|..|.::
Zfish   205 VTVMDYLSYAIYQQGELDRALELTKRMLKLDPNHHRANGNLKYFEFQLEKQRKAENEKKEEDQKR 269

  Fly   263 LISS-ELKQWINDDSTTPPTDHNLGCRG----LFPKK-SNLVCRY-NSSTNAFLKLAPLKMEEIS 320
            ::.. :.::..:.|.......:...|||    |.|:: |.|.||| |::.|..|.|||:|.|:..
Zfish   270 VLDKRDAQRKRSKDPLPERKKYERLCRGEGIKLTPRRQSRLFCRYSNNNRNPRLLLAPVKQEDEW 334

  Fly   321 RDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDP--------KEIVSRVYWIR-KESSFSKR 376
            ..|.||.:||:|||.:||.:| |:.:......::.:|        ...:|:..|:. .|.|..:|
Zfish   335 DRPRIVRYHEIISDSEIETVK-EMAKPRLRRATISNPITGVLETAPYRISKSAWLSGYEHSTIER 398

  Fly   377 INQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDVNNTL--GDRIGSIIFYAGE 439
            |||||.|:||.:::....:|:||:||||.::||:||  .|..|.|....|  |:||.:.:||..:
Zfish   399 INQRIEDVTGLEMDTAEELQVANYGVGGQYEPHFDF--GRKDEPDAFKELGTGNRIATWLFYMSD 461

  Fly   440 VSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQLF 504
            ||.||.|||.|:..||.||||.|:||:|.|.....|..:.|:.||||||::|...||:|...|.|
Zfish   462 VSAGGATVFTDVGAAVWPKKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEF 526

  Fly   505 VKPCS 509
            .:||:
Zfish   527 RRPCA 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	33/131 (25%)
		ATP-synt_B	<198..278	CDD:304375	13/97 (13%)
		P4Hc	333..498	CDD:214780	70/175 (40%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	33/131 (25%)
		TPR repeat	164..199	CDD:276809	8/34 (24%)
		TPR_16	168..238	CDD:290168	10/69 (14%)
		TPR repeat	204..234	CDD:276809	4/29 (14%)
		P4Hc	347..520	CDD:214780	70/175 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920