DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18234 and p4htmb

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_001340234.2	Gene:	p4htmb / 799930	ZFINID:	ZDB-GENE-110131-7	Length:	510	Species:	Danio rerio

Alignment Length:	339	Identity:	64/339 - (18%)
Similarity:	119/339 - (35%)	Gaps:	104/339 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 LLRKDIYEVGKIDVPDPTFIITPWFDVTGC---LRVGQ-----TSQHLSCHYEKNTSEFLRIAPL 307
            |:...::|:..:.:....|.|..:.....|   :|:.|     .||.:....::...:.|.::|.
Zfish   140 LVSGKVHEMKTLSLKPLLFEIPDFLSEEECAVVVRLAQLKGLMESQVMVPEGQEELDQQLNLSPE 204

  Fly   308 KV-------ETLSLKPHIVLYHDVIYDSEISKVKNIS--LPSLKSPL--RILYAIDYNLKFAKIR 361
            ::       :...|:||.:|.|..:.|......:|:.  ...||:.|  ..|.:::   :|.::|
Zfish   205 EIFNFLDLNQDGQLQPHEILTHSRVRDGIWLTSENLKEIYDGLKADLDGNGLLSLE---EFGRLR 266

  Fly   362 ED-------------------------------HQSPLSLR-----IKDMTGEDVQEDTDFQIDN 390
            .|                               ||....||     :..:....|:.....|:..
Zfish   267 SDAFQRFLLQRGVERSQLVRNSRHTWLYQGQGAHQVLQDLRKRVTLLTRLPSSLVELSEPLQVVR 331

  Fly   391 YGICGFRNFHTDNIELQDQTA--------------ELGDRLTSIMFFMNDVAQGGALAFP----- 436
            |...|..:.|.|:..:..:||              :...|..:::|::|:|.:||...||
Zfish   332 YEQGGHYHAHHDSGPVYPETACTHTRLAANTTSPFQTSCRYITVLFYLNNVQEGGETTFPVADNR 396

  Fly   437 ----------------------NLNLTIWPQKGSALVWRNL--DHR---MQPNQDLLHVSCPVVV 474
                                  ..||.:.|.||:|:.|.|.  |.|   .:.::..||..|.|..
Zfish   397 TYEEASLIQNDVDLLDTRKHCDKGNLRVKPVKGTAVFWYNYLSDGRGWVGEQDEYSLHGGCVVTQ 461

  Fly   475 GSKWTLVKWLHERP 488
            |:||....|::..|
Zfish   462 GTKWVANNWINVDP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	35/164 (21%)
p4htmb	XP_001340234.2	EF-hand_7	204..262	CDD:290234	11/60 (18%)
		EFh	204..262	CDD:298682	11/60 (18%)
		P4Hc	285..471	CDD:214780	37/185 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740