DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and CG34345

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	153/501 - (30%)
Similarity:	243/501 - (48%)	Gaps:	70/501 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLI 91
            ||..:.||.::|..::..:.:|.:.|:.||..:...:..:.......:.:..::|::|||:|.|:
  Fly    40 SIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLNSFGLL 104

  Fly    92 RRLHEDWTQAELLMLNQ----VGLEHLQAIETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDI 152
            ||.|:||.:....:.:|    |.:|.:..    |....|..||:.:|:.|:..::.||:|:.||:
  Fly   105 RRAHQDWPKLIAYLKDQGNIKVDIEEMNK----LINRTPHANDMEEALMGMDRIEHFYDLKSSDM 165

  Fly   153 ANGLLMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKAAVDHYNDDRDGQVYREVFDFRLPD 217
            |.||:.|||.::.::..:|.|||:.....:..:.|..|::.|:..:...::    ...|.|..|.
  Fly   166 AQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTKPKN----NIAFKFYAPK 226

  Fly   218 LYINYTSVLVTKGFRKAAWKV-----LQD--VADLDATLWLLRKDIYEVGKIDVPDPTFI----- 270
                          ||...|:     ||:  |.:|...|..|.:|         |:.:.:
  Fly   227 --------------RKELEKMFVISRLQEGSVENLTDCLKELSQD---------PNNSLVHLRPR 268

  Fly   271 ITPWFDVTGCLRVGQTSQHLSCHYEKNTSEFLRIAPLKVETLSLKPHIVLYHDVIYDSEISKVKN 335
            .:|.....||.........|.|.|...|:.|:||||||.|.:|..|.|.|||||||||||:::.|
  Fly   269 KSPTMIEQGCQGKFPPGPQLVCRYNSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTN 333

  Fly   336 ISLPSL--------KSPLRI--LYAIDYNLKFAKIREDHQSPLSL----RIKDMTGEDVQEDTDF 386
            ::...:        .:|.|:  |:.|       |:.:|....|..    |:.|::|.||...|..
  Fly   334 VTREEMILGTTTNYTTPDRVNRLFHI-------KVTDDDGGKLDKTLVNRMADISGLDVGNTTTL 391

  Fly   387 QIDNYGICGFRNFHTD--NIELQDQTAELGDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSA 449
            ...|||:.|:...|:|  :|:|..:..|.||||.:.:|:|.||..||...||...|.|.|:||||
  Fly   392 ARINYGLGGYFQEHSDYMDIKLYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSA 456

  Fly   450 LVWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVKWLHERPQMFSRPC 495
            |.|.||.:...||....|..||.:|||:|.|||.:....|||.:||
  Fly   457 LFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	36/133 (27%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	50/115 (43%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	36/133 (27%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	61/171 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461928
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900