DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and p4ha3

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_021322008.1	Gene:	p4ha3 / 563281	ZFINID:	ZDB-GENE-041010-4	Length:	616	Species:	Danio rerio

Alignment Length:	563	Identity:	134/563 - (23%)
Similarity:	223/563 - (39%)	Gaps:	131/563 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFIILSICLISLGPPIGLCEITNSAMSIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQE 65
            :||:|  .|::: |.....|:..|.:|:   .:.|..|...|..:..|......:::.::.....
Zfish     7 LFIVL--YLLNM-PDESFGEMFTSMLSV---NQAVSAERKLIDHLIIYIEHEAQRLEDIKRFFSR 65

  Fly    66 VQSKREISRRNPEEFVAHPLNAFSLIRRLHEDW------TQAELLMLNQVGLEHLQAIETG---L 121
            |.|..:.....|.:.:|:|:.||.|::||..:|      |:||         |:::.:...   :
Zfish    66 VTSLHDGIYNEPSDPIANPIAAFKLVKRLKSEWLNVVHSTEAE---------ENIKVLREDYRRM 121

  Fly   122 EEAQPSDNDLNDAIGGIISLQQFYNLQPSDIANGLLMGQQYNASLTTLNCQALANACMNFNYDKY 186
            |.:.|...||..|..|::.||..|||....:..|                        :|.....
Zfish   122 ESSLPKLEDLRGAAHGLMRLQDVYNLHVESLVRG------------------------HFQQISD 162

  Fly   187 ALNWFKAAVDHYNDDRD----GQVYREVFDFRLPDLYINYTSVL----VTKGFRKAAWK-----V 238
            .::::|.:|.......|    |:|..::.|:        |.|||    ..:.||...|.     .
Zfish   163 PVDFYKLSVSDMLSGDDCFLVGKVAYDLEDY--------YHSVLWFEEAVRLFRGTEWSPENEGT 219

  Fly   239 LQDVAD---------------LDATLWLL------RKDIYEVGKIDV-----------------P 265
            |:|..|               |..:..||      |:..:.|.|.:.                 |
Zfish   220 LEDALDHLAFSHFKTGNISHALSLSRELLLHDPMNRRVHFNVEKYEKLLNENLPATSSGLTLKRP 284

  Fly   266 DPTFIITPWFDVTGCLRVGQTSQH-----LSCHYEKNTSEFLRIAPLKVETLSLKPHIVLYHDVI 325
            |..::.|.......|...|...:|     |.|.|..|.|..|.:.|::.|.:||:|::||:|..:
Zfish   285 DGIYLRTRNAYEQLCQTKGSQPKHFENPSLFCDYFTNGSPALFLQPIRREIISLQPYVVLFHGFV 349

  Fly   326 YDSEISKVKNISLPSLKSPLRILYAIDYNLKFAKIR---------EDHQ--SPLSLRIKDMTGED 379
            ..:|...::..::|.|:   |.:.|...|...|:.|         ..|:  ..|..||..:||.:
Zfish   350 TQAEAKNIRKYAMPGLR---RSVVASGMNQATAEYRISKSAWLKESAHEVVGKLDQRITLVTGLN 411

  Fly   380 VQED--TDFQIDNYGICGFRNFHTDNIELQDQ---TAELGDRLTSIMFFMNDVAQGGALAFPNLN 439
            ||..  ...|:.||||.|....|.|:......   ..:.|:|:.:||.:::.|..||:.||...|
Zfish   412 VQPPYAEYLQVVNYGIGGHYEPHFDHATSDSSPLYRLKTGNRVATIMIYLSPVQAGGSTAFIYAN 476

  Fly   440 LTIWPQKGSALVWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVK 482
            .::...:.:||.|.||....|.|.|.||..|||:||:||.:.|
Zfish   477 FSVPVVQNAALFWWNLHKNGQGNVDTLHAGCPVIVGNKWGMFK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	32/138 (23%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	42/117 (36%)
p4ha3	XP_021322008.1	P4Ha_N	27..157	CDD:311993	33/165 (20%)
p4ha3	XP_021322008.1	P4Hc	350..519	CDD:214780	51/171 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850