DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and zgc:152670

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001070123.2	Gene:	zgc:152670 / 557059	ZFINID:	ZDB-GENE-060929-954	Length:	490	Species:	Danio rerio

Alignment Length:	505	Identity:	138/505 - (27%)
Similarity:	214/505 - (42%)	Gaps:	80/505 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLI 91
            |:..:.:|.:.|...:.....|..|.:..:..|:|||..:|.....:.::|||.:..|:.||.|:
Zfish    26 SVDQVSQLFNEEENLLDTFSLYIDAEEENLKKMKSLLLLLQLGSFSNPQSPEETMRDPVAAFKLL 90

  Fly    92 RRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQ-PSDNDLNDAIGGIISLQQFYNLQPSDIA-- 153
            :||..:|  ..:....|..|  .|..:|.|:.:. |...|:|.|..|:|.||:.|.|.|.:|.
Zfish    91 KRLRHEW--VNIAKFTQQSL--YQEFQTLLDYSLIPELEDINSAALGLIGLQEIYKLYPHNITKE 151

  Fly   154 NGLLMGQQYNASLTTLNCQALANACMNFNYDKY--ALNWFKAAVDHYND-------DRDGQVYRE 209
            ..|...:.|...|..            :..||:  |..||..:::...|       |....:...
Zfish   152 TPLSADEAYYIGLVA------------YEEDKFQHAFLWFLHSLNRLTDFSSTTKNDLLRFLSSS 204

  Fly   210 VFDFRLPDLYINYTSVLVTKGFRKAAWKV---------LQDVADLDA-TLWLLRKDIYEV---GK 261
            .:.|....:.|.:...|:.........||         ||..::.|. ||.....:.||.   |:
Zfish   205 AYQFGSLPVAIYFGQKLLNLDPSNEEIKVQLGLYRLIRLQRTSNPDIFTLNTQSNNSYEALCRGE 269

  Fly   262 IDVPDPTFIITPWFDVTGCLRVGQTSQHLSCHYEK-NTSEFLRIAPLKVETLSLKPHIVLYHDVI 325
            :|.                 |..:..:.|||.|.. ..:..|..||:|.|.|..:|.|:.|||||
Zfish   270 VDE-----------------RTSKRQRALSCRYSTGGGNPRLMYAPVKEEELWDEPKIIRYHDVI 317

  Fly   326 YDSEISKVKNISLPSLK---------SPLRILYAIDYNLKFAKIREDHQSPLSLRIKDMTGEDVQ 381
            .|:||..:|:|:.|.|.         |.:|...::.........|      :|.||.|:||..|:
Zfish   318 SDTEIETLKDIARPELTRSQTGWGVISDIRTSQSVFLEEVGTVAR------ISQRIADITGLSVE 376

  Fly   382 EDTDFQIDNYGICGFRNFHTDNIELQDQTAELGDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQK 446
            ......:.||||.|....|.|..:      |:.:|..:.:.:|:||..|||..|.|:.:.:.|:|
Zfish   377 SAEKLHVQNYGIGGRYTPHFDTGD------EVNERTATFLIYMSDVEVGGATVFTNVGVAVKPEK 435

  Fly   447 GSALVWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVKWLHERPQMFSRPCT 496
            |||:.|.||....:.:....|..|||:||:||...||:||..|.|.|||:
Zfish   436 GSAVFWYNLHKNGELDLKTKHAGCPVLVGNKWVANKWIHEFGQEFRRPCS 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	37/132 (28%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	41/113 (36%)
zgc:152670	NP_001070123.2	P4Ha_N	26..150	CDD:285528	37/127 (29%)
zgc:152670	NP_001070123.2	P4Hc	318..474	CDD:214780	52/167 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920