DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and p4ha2

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	556	Identity:	144/556 - (25%)
Similarity:	242/556 - (43%)	Gaps:	96/556 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IILSICLISLGPPIGLCEITNSAMSIAG-MKELVDLEGFFISEMESYTAALKNKIDLMESLLQEV 66
            |:||:|.|        .|:.....:..| |.:|:..|...:..::.|....:.::..::....||
Frog     9 ILLSLCCI--------WEVQTEVFTSTGQMTDLIFRERDLLQSLKEYIREEEERLSKIKRWASEV 65

  Fly    67 QSKREISRRNPEEFVAHPLNAFSLIRRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQPSDNDL 131
            ......|..:||.::.||:||:.|::|.:.||:..|.|:| |...:...|..|...|..|::.|.
Frog    66 DELSSRSTADPEGYLGHPVNAYKLVKRFNTDWSSLENLVL-QDSAKGFIANFTFQREYFPTEEDE 129

  Fly   132 NDAIGGIISLQQFYNLQPSDIANGLLMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKAAVD 196
            ..|...::.:|..|.|.|..||.|.|.|..|.:||:..:...:.....:.....:.:.|.:.|:.
Frog   130 TGAARALMRIQDTYKLDPDVIAKGKLPGTNYISSLSADDSFGMGKIAYHDGDYYHTVLWMQQALK 194

  Fly   197 HYNDDRDGQVYR-EVFDFRLPDLYINYT--------------------------SVLVTKGFRKA 234
            ..::..|..|.: :|.|      |::||                          :|...|.|.|.
Frog   195 QMDEGEDAVVNKVDVLD------YLSYTVFQLGDVPRALELTKRLLALDPNHDRAVNNLKYFEKM 253

  Fly   235 AWKVLQDVADLDATL----------------WLLRKDIYEV---GKIDVPDPTFIITPWFDVTGC 280
            ..|...::...::|.                :|..:|:||.   |:                 |.
Frog   254 QEKQKAELKQNESTNTESATRQPGVYSRPLDYLPERDVYEALCRGE-----------------GV 301

  Fly   281 LRVGQTSQHLSCHYEK-NTSEFLRIAPLKVETLSLKPHIVLYHDVIYDSEISKVKNISLPSL-KS 343
            ....:..:.|.|.|.. |.|.:|.::|:|||.....|.||.|.:.:.|.||:|:|.::.|.| ::
Frog   302 KMNPRRQRRLFCRYHNGNRSPYLILSPVKVEDEWDSPRIVRYLNALSDEEIAKIKELAKPKLARA 366

  Fly   344 PLR-----ILYAIDYNLKFAKIREDHQSP----LSLRIKDMTGEDVQEDTDFQIDNYGICGFRNF 399
            .:|     :|...:|.:..:...|::..|    ::||::.:||..|......|:.|||:.|....
Frog   367 TVRDPKTGVLSVANYRVSKSAWLEENDDPVIARVNLRMQAITGLTVDTAELLQVANYGMGGQYEP 431

  Fly   400 HTDNIELQDQ-----TAELGDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSALVWRNLDHRM 459
            |.| ...:|:     ....|:|:.:.:.:|:||..|||..||:....|||:||:|:.|.||....
Frog   432 HFD-FSRKDEPDVFKRLGTGNRVATFLNYMSDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSG 495

  Fly   460 QPNQDLLHVSCPVVVGSKWTLVKWLHERPQMFSRPC 495
            :.:....|.:|||:|||||...||.|||.|.|.|||
Frog   496 EGDYRTRHAACPVLVGSKWVSNKWFHERGQEFLRPC 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	35/130 (27%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	42/118 (36%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	22/86 (26%)
		TPR repeat	166..201	CDD:276809	2/34 (6%)
		TPR repeat	206..236	CDD:276809	5/35 (14%)
		P4Hc	348..521	CDD:214780	55/173 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010