DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18234 and PH4alphaNE2

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	164/538 - (30%)
Similarity:	258/538 - (47%)	Gaps:	65/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IILSICLISLGPPIGLCEITNS----AMSIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLL 63
            ::|.:..:||.  .|.....|:    |.|:..|.::::||...:|.:|....||..|...::..:
  Fly     7 VLLGMLYLSLS--FGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGV 69

  Fly    64 QEVQSKREISRRNPEEFVAHPLNAFSLIRRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQPSD 128
            .::..:|:..:.:.|.| |:|::.|||||.:..:|....|.:...||.|.|..:::.: ...|..
  Fly    70 FKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRM-PLLPKY 132

  Fly   129 NDLNDAIGGIISLQQFYNLQPSDIANGLLMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKA 193
            .|..||..||..:|..|.:..||||.|||.|.|||:||..::|.|:....||.:....|..|..|
  Fly   133 FDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISA 197

  Fly   194 AVDHYNDDRDGQVYREVF-DFRLPDLYINYTSVLVTKGFRKAAWKVLQDVADLDATLWLLRKDIY 257
            :::.| |.:..|...|:. ..:|.||......|.:.:...:.|.:..|....|...    ..:||
  Fly   198 SIEAY-DQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPH----DPEIY 257

  Fly   258 EVGKI------------------DVPDPTFIITPWFDVTGCLRVGQTSQHLSCHYEKNTSEFLRI 304
            |..:|                  |......::.|.  .:|..:|.:...:|.|.|...||.||::
  Fly   258 EEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPC--CSGRCQVPRNLSNLYCVYNHVTSPFLQL 320

  Fly   305 APLKVETLSLKPHIVLYHDVIYDSEISKVKNIS----LPS----------------LKSPLRILY 349
            ||:|.|.||:.|.:||.||:|...|.:.::..|    |||                .::...:.|
  Fly   321 APIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWY 385

  Fly   350 AIDYNLKFAKIREDHQSPLSLRIKDMTGEDVQEDTDFQIDNYGICGFRNFHTDNIELQDQTAELG 414
            :.|:|....||.|        |:.|.||.|:.....:|:.|||:.||...|.|.: |.::....|
  Fly   386 SSDFNDTTKKITE--------RLGDATGLDMNSTEFYQVINYGLGGFFETHLDML-LSEKNRFNG 441

  Fly   415 --DRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSALVWRNLDHRMQPNQDLLHVSCPVVVGSK 477
              ||:.:.:|::|:|.|||...||.||||::||.||||.|.|||.:...:...||..|||:||||
  Fly   442 TSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSK 506

  Fly   478 WTLVKWLHERPQMFSRPC 495
            |.:.||:::..|.|:|||
  Fly   507 WVMSKWINDMGQEFTRPC 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	38/129 (29%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	51/115 (44%)
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	38/129 (29%)
		TPR repeat	175..200	CDD:276809	7/24 (29%)
		TPR_16	176..254	CDD:290168	17/82 (21%)
		TPR repeat	219..249	CDD:276809	6/29 (21%)
		TPR_2	220..253	CDD:285020	6/36 (17%)
		P4Hc	342..513	CDD:214780	61/179 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461933
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900