DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and CG15539

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	152/502 - (30%)
Similarity:	244/502 - (48%)	Gaps:	50/502 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NSAMSIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNA 87
            |.|:||..|.:|:|.|.:.::.::.:..||:.::|.:|..|:.....||      :.....|:..
  Fly    29 NYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTDYDRE------KNLAEDPIKH 87

  Fly    88 FSLIRRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDI 152
            |.:.||||.|:......|..|.....::.| ..:....|:..|:.:||.|:..:|..|:|..:::
  Fly    88 FRITRRLHSDYVNWVWFMEEQPWGTLVKDI-IAIAPEMPTLKDVEEAIRGLRLIQWTYSLPTAEM 151

  Fly   153 ANGLLMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKAAVDHYNDDRDGQVYREVFDFRLPD 217
            |.|:|....:|.||..:.|..:|...:|:.....|..|....:..|..|.:.:.........|.|
  Fly   152 AKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEEIEYIYSQLGMPLVD 216

  Fly   218 LYINYTSVLVTKGFRKAAWKVLQ-------DVADLDATLWLLRKDIYEVGKIDVPDPTFIITPWF 275
            .|..:..:....|.|..|...||       :...|...|..|:.:| .:||    :|.
  Fly   217 FYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSLQRALSRLKMNI-RIGK----EPA------- 269

  Fly   276 DVTG---------CLRVGQTSQHLSCHYEKNTSEFLRIAPLKVETLSLKPHIVLYHDVIYDSEIS 331
            :...         |....:.:..|.|.|:..:|.|||:||||:|.|||.|::||:|||:.|.:|.
  Fly   270 EKKNKSKRVYKKCCSSECRPTAKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIV 334

  Fly   332 KVKNISLPSLKSPLRILYAIDY------NLKFAKIREDHQ--SPLSLRIKDMTGEDVQEDTDFQI 388
            .::|::...|...:.:....:|      ..|...:.|::.  ..||...:|||..|:.:...||:
  Fly   335 SIRNLTKGKLARTVTVSKDGNYTEDPDRTTKGTWLVENNALIQRLSQLTQDMTNFDIHDADPFQV 399

  Fly   389 DNYGICGFRNFHTDNIELQDQTAEL---GDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSAL 450
            .||||.||...|.|.:|    .|||   .||:.:.:|:::||.||||..||.|.|:::|:|||||
  Fly   400 LNYGIGGFYGIHFDFLE----DAELDNFSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSAL 460

  Fly   451 VWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVKWLHERPQMFSRPCTT 497
            :|.||||:...:....|.:||.||||:|.:.||::||.|:|.|||.|
  Fly   461 LWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFRRPCLT 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	33/129 (26%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	52/116 (45%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/129 (26%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	60/168 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461936
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900