DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and CG18749

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	160/531 - (30%)
Similarity:	249/531 - (46%)	Gaps:	88/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFII--------LSICLISLGPPIGLCE-ITNS------AMSIAGMKELVDLEGFFISEMESYTA 50
            |:|:        ||.|.|:       |: ..||      |.|...:.:|:::|...:..::.|..
  Fly     1 MYILKKLTFIGFLSACFIN-------CQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVK 58

  Fly    51 ALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLIRRLHEDWTQ--AELLMLNQVGLEH 113
            .||.|.:|||..|.::..:....:.:.|.::.:|||:|.||.|||..|.:  ...:.:....|.|
  Fly    59 TLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGH 123

  Fly   114 LQAIETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDIANGLLMG-QQYNASLTTLNCQALANA 177
            ::.... :.:..|:.:||..|..||..|..||:|:|.::|.|.|.| .|....||..:|.||...
  Fly   124 IENARL-MRKMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEF 187

  Fly   178 CMNFNYDKYALNWFKAAVDHYNDDRDGQVYREVFDFRLPDLYINYTSVLVTKGFRKAAWKVLQDV 242
            .:....|..|..|:..::..:::                         ::.|.....||
  Fly   188 GVQNQKDDLAEAWYNLSLTRFDN-------------------------IIEKYQVHKAW------ 221

  Fly   243 ADLDATLWLLRKDIYEVGKIDVPDPTFIITP----WFD-----VTGCLRVGQ-TSQHLSCHYEKN 297
                |.|....|.:.|..:.....|..|:..    .|:     ...|..|.| .|:.|.|.|..:
  Fly   222 ----ALLLAKNKQLTEAFQHFENKPEGIVASNEVIHFEGVLATTQNCTAVVQKPSKKLHCRYNTS 282

  Fly   298 TSEFLRIAPLKVETLSLKPHIVLYHDVIYDSEISKVKNI-------SLPSLKSPLRILYAIDYNL 355
            |:.|.||||||:|.|.|.|::|::||||||:||..:.|.       |:..|||.:|.  :.|.::
  Fly   283 TTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSDFGLSESVSGLKSEVRT--SKDSHI 345

  Fly   356 KFAKIREDHQSPLSLRIKDMTGEDVQEDTDFQIDNYGICGFRNFHTDNIELQDQT-AELGDRLTS 419
            ..||       .|:.|:.||||..::....|.:.|||:.|....|.|..|..:.| .:.|||:.:
  Fly   346 VDAK-------TLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDFHEYTNTTRLKQGDRIAT 403

  Fly   420 IMFFMNDVAQGGALAFPNLNLTIWPQKGSALVWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVKWL 484
            ::|::.:|..|||..||.||:|:.|:||||:.|.||.:....|...||.:|||:.|||:.|.||:
  Fly   404 VLFYLREVDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWI 468

  Fly   485 HERPQMFSRPC 495
            :|.||||..||
  Fly   469 NELPQMFVTPC 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	37/131 (28%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	47/114 (41%)
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	37/131 (28%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	58/162 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461944
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	8	7.890