DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18234 and P4ha2

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	145/530 - (27%)
Similarity:	239/530 - (45%)	Gaps:	83/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLI 91
            ||..|.:|:..|...:..::.|..|.:.|:..::|...::::....|..:||.::|||:||:.|:
  Rat    26 SIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNAYKLV 90

  Fly    92 RRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDIANGL 156
            :||:.||.....|:|.......:..:.. ..:..|:|.|.:.|...::.||..|.|.|..|:.|.
  Rat    91 KRLNTDWPALGDLVLQDAAAGFVANLSV-QRQFFPTDEDESGAARALMRLQDTYKLDPDMISRGE 154

  Fly   157 LMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKAAVDHYNDDRDGQVYRE-VFD------FR 214
            |.|.:|.|.|:..:|..:..:..|.....:.:.|.:..:...:...:..|.:. |.|      |:
  Rat   155 LPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATVTKSLVLDYLSYAVFQ 219

  Fly   215 LPDLY--INYTSVLVT--------KGFRKAAWKVLQDVA------DLDATL------------WL 251
            |.||:  :..|..|::        .|..:...::|::..      ..||.|            :|
  Rat   220 LGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAGLASQENLYERPVDYL 284

  Fly   252 LRKDIYEV---GKIDVPDPTFIITPWFDVTGCLRVGQTSQHLSCHYEK-NTSEFLRIAPLKVETL 312
            ..:|:||.   |:                 |.....:..:.|.|.|.. |....|.|||.|.|..
  Rat   285 PERDVYESLCRGE-----------------GIKMTPRRQKRLFCRYHHGNRVPQLLIAPFKEEDE 332

  Fly   313 SLKPHIVLYHDVIYDSEISKVKNISLPSL-KSPLR-----ILYAIDYNLKFAKIREDHQSP---- 367
            ...||||.|:||:.|.||.::|.|:.|.| ::.:|     :|....|.:..:...|:...|
  Rat   333 WDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVAR 397

  Fly   368 LSLRIKDMTGEDVQEDTDFQIDNYGICGFRNFHTDNIELQDQTA----ELGDRLTSIMFFMNDVA 428
            ::.|::.:||..|:.....|:.|||:.|....|.|.....::.|    ..|:|:.:.:.:|:||.
  Rat   398 VNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERDAFKRLGTGNRVATFLNYMSDVE 462

  Fly   429 QGGALAFPNLNLTIWPQKGSALVWRNL------DHRMQPNQDLLHVSCPVVVGSKWTLVKWLHER 487
            .|||..||:|...|||:||:|:.|.||      |:|.:      |.:|||:||.||...||.|||
  Rat   463 AGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTR------HAACPVLVGCKWVSNKWFHER 521

  Fly   488 PQMFSRPCTT 497
            .|.|.|||.|
  Rat   522 GQEFLRPCGT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	35/129 (27%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	44/123 (36%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	21/76 (28%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	56/178 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920