DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and PH4alphaSG1

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	149/562 - (26%)
Similarity:	247/562 - (43%)	Gaps:	111/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IILSICLISLGPPIGLCEITNSAMSIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQ 67
            ||||  |:.:.|..|     :...:|:.::.|:|:|.|.:.:.:.|....:.:.:.::..|.::.
  Fly     6 IILS--LLCVFPVNG-----DYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQID 63

  Fly    68 SKREISRRNPEEFVAHPLNAFSLIRRLHEDWTQAELLMLNQV-GLEHLQAIETGLEEA------- 124
            .::. .|.:.||:..:|:|||..|:||..||   :..:.:.| ...:.:..:..|.::
  Fly    64 EQQN-DRGDLEEYFGNPINAFITIKRLVHDW---KFNVFDPVFDSSNFETYKNNLSDSLEKINFK 124

  Fly   125 QPSDNDLNDAIGGIISLQQFYNLQPSDIANGLLMGQQYNA---SLTTLNCQALA-NACMNFNYDK 185
            .|:..||:.|...::.||..|.|....:|:|:|...:.||   ||:..:|..|. |.|....| .
  Fly   125 GPTQEDLHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEY-S 188

  Fly   186 YALNWFKAAVDHYNDDRDGQVYREVFDFRLPDLYINYTSVLVTKGFRKAAWKVLQDVADL--DAT 248
            |...|...|....:....|.:...|.|..:.:   :.:|.....|..|.|:|:..::.|.  |..
  Fly   189 YGSEWLLEARKRLHGKPLGFISPNVSDVEILE---HLSSAFNGLGNLKLAYKLNNEILDKKPDHE 250

  Fly   249 LWLLRKDIYEVG------------KIDVPDPTFIITPWFDVTGCLRVGQTSQ------------- 288
            ..|..|.:|| |            ::::|                ::.:..|
  Fly   251 EALKNKILYE-GQLARERSFAPRKQVELP----------------QIAEKEQKESYKLYTQVCRG 298

  Fly   289 --HLSCHYEKNTS--------EFLRIAPLKVETLSLKPHIVLYHDVIYDSEI------------- 330
              |.|...::|..        .:.|::|.|:|.|::.|::...|:|::||||
  Fly   299 ELHQSPREQRNLRCWLYHQGVPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMER 363

  Fly   331 SKVKNISLPSLKSPLRI-----LYAIDYNLKFAKIREDHQSPLSLRIKDMTGEDVQEDTDFQIDN 390
            |||.. |..|..|.:||     |: .|.|...:||::        |::|:||...:.....|:.|
  Fly   364 SKVGQ-SENSTTSEVRISRNTWLW-YDANPWLSKIKQ--------RLEDVTGLSTESAEPLQLVN 418

  Fly   391 YGICGFRNFHTDNIELQDQT--AELGDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSALVWR 453
            |||.|....|.|.:|...|:  :..|:||.:.:|::||||.|||.|||.|.|.:.|.|||.|:|.
  Fly   419 YGIGGQYEPHFDFVEDDGQSVFSWKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWY 483

  Fly   454 NLDHRMQPNQDLLHVSCPVVVGSKWTLVKWLHERPQMFSRPC 495
            ||......:....|..|||:.||||...:|.|...|.|.|||
  Fly   484 NLHSSTHKDFRTKHAGCPVLQGSKWICNEWFHVGAQEFRRPC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	31/137 (23%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	47/115 (41%)
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	31/137 (23%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	64/177 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461925
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900