DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18234 and CG32201

DIOPT Version :9

Sequence 1:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	160/501 - (31%)
Similarity:	250/501 - (49%)	Gaps:	50/501 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLI 91
            |..|:.:|:.:|..|...:.:....|..|.:.:...|..|..:...|.....::|::|:|||||:
  Fly    36 STVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYLSSVGYELHRSLNEKVQYVSNPINAFSLL 100

  Fly    92 RRLHEDWTQAELLMLNQVGLEHLQAIETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDIANGL 156
            ||.|||..:........:| |..|:|...|.:..|:|.|:..|:.||..:::.|:|:..|:|.|:
  Fly   101 RRTHEDLPKWHEYFKEAIG-EGNQSILVDLVKMVPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGV 164

  Fly   157 LMGQQYNASLTTLNCQALANACMNFNYDKYALNWFKAAVDHYNDDRDGQVYREVFDFRLPDLYIN 221
            |.|.|||..||..:..|:.|:....:..:.|..|::.|.....::.: |::.::.......|:..
  Fly   165 LQGVQYNVQLTYRDLIAMGNSMYQQSDYQTAAKWYRIACKRELENPE-QLFIQILGDPSEHLHRQ 228

  Fly   222 YTSVLV---------TKGFRKAAWKVLQDVADLDATLWLL---------RKDIYEVGKIDVPDPT 268
            |...|.         :|...:|...|.....:||..:..|         .||:|:|.:
  Fly   229 YIKSLFKYGSTTSEPSKSIEEAFIMVQASQEELDNIMSDLNEPQNDVEVEKDLYQVKR------- 286

  Fly   269 FIITPWFDVTGCLRVGQTSQHLSCHYEKNTSEFLRIAPLKVETLSLKPHIVLYHDVIYDSEISKV 333
               :|.....||..:.:...:|.|.|:...:.|||:||||:|.:||.|.:.:||:|:|||||.::
  Fly   287 ---SPSNCELGCRGLYRQKTNLVCRYKSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIREL 348

  Fly   334 KNISLPSLKSPLRILYAIDYN---LKFAKIREDHQSPLSL-------RIKDMTGEDVQEDTDFQI 388
            |..|:..:..     ||...|   ::...:|.|..|..||       ||.||||.:..:|...||
  Fly   349 KGQSMNMVNG-----YASQRNGTEIRDTVVRYDWWSNTSLVRERINQRIIDMTGFNFLKDEKLQI 408

  Fly   389 DNYGICGFRNFH----TDNIELQDQTAELGDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSA 449
            .|||:..:...|    :|..|..:.|. |||||.||:|:.::|.||||..||.:|:|::|||||.
  Fly   409 ANYGLGTYFQPHFDYSSDGFETPNITT-LGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSM 472

  Fly   450 LVWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVKWLHERPQMFSRPC 495
            |.|.||....:|:...||..|||:.|.:|||.||:...|||||.||
  Fly   473 LYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	38/129 (29%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	54/117 (46%)
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	38/129 (29%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	68/171 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461927
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900