DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4174 and p4htmb

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	XP_001340234.2	Gene:	p4htmb / 799930	ZFINID:	ZDB-GENE-110131-7	Length:	510	Species:	Danio rerio

Alignment Length:	366	Identity:	66/366 - (18%)
Similarity:	125/366 - (34%)	Gaps:	130/366 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LELALYHYDDNVSPE--VLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLT 254
            |:..|:...|.:|.|  .:.::|.....|:||.|...:|       ::..::.|:::|...:...
Zfish   153 LKPLLFEIPDFLSEEECAVVVRLAQLKGLMESQVMVPEG-------QEELDQQLNLSPEEIFNFL 210

  Fly   255 QLPKLKHLQSNPAKLTKPKKVFQLQKEICSKRYRRKSGVLVCRYVDWTPFLKLAP---------- 309
            .|.:...||  |.::....:|              :.|:       |.....|..
Zfish   211 DLNQDGQLQ--PHEILTHSRV--------------RDGI-------WLTSENLKEIYDGLKADLD 252

  Fly   310 ----LKMEELSMKPYISIFYGFLGQKDIE---VLKNVSRPKLQRIEHLSGNCSCKIGNLSTSLHD 367
                |.:||.. :.....|..||.|:.:|   :::|.....|.:               ....|.
Zfish   253 GNGLLSLEEFG-RLRSDAFQRFLLQRGVERSQLVRNSRHTWLYQ---------------GQGAHQ 301

  Fly   368 VVRKVNELILGITGFP---LKGNQMLEVINYGIAGNYN---------PEEPKIHNKANA------ 414
            |::.:.:.:..:|..|   ::.::.|:|:.|...|:|:         ||....|.:..|
Zfish   302 VLQDLRKRVTLLTRLPSSLVELSEPLQVVRYEQGGHYHAHHDSGPVYPETACTHTRLAANTTSPF 366

  Fly   415 ---------FIFLSNAGKGGEIVFP----------------------SRH-----LKVRPRKGSM 443
                     ..:|:|..:|||..||                      .:|     |:|:|.||:.
Zfish   367 QTSCRYITVLFYLNNVQEGGETTFPVADNRTYEEASLIQNDVDLLDTRKHCDKGNLRVKPVKGTA 431

  Fly   444 LVWENL-----------KKSLIYHQCPILKGNMWVANKVLN 473
            :.|.|.           .:..::..|.:.:|..||||..:|
Zfish   432 VFWYNYLSDGRGWVGEQDEYSLHGGCVVTQGTKWVANNWIN 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528
		TPR repeat	169..197	CDD:276809	1/4 (25%)
		TPR repeat	202..245	CDD:276809	9/44 (20%)
		2OG-FeII_Oxy	<362..470	CDD:304390	33/172 (19%)
p4htmb	XP_001340234.2	EF-hand_7	204..262	CDD:290234	10/80 (13%)
		EFh	204..262	CDD:298682	10/80 (13%)
		P4Hc	285..471	CDD:214780	36/200 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840