DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and P4ha1

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	131/515 - (25%)
Similarity:	222/515 - (43%)	Gaps:	87/515 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPRNL----IYGY 89
            |..|......|:..::..|.:|:.|.|..:..|::|::...:.:.|..:....|...    :..:
  Rat    21 FFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAF 85

  Fly    90 KVLRHLHNDWPQYFRLLKKDL--GLEQIAVSQMLLTQQ--PTSVDFEESMGAMHRLQTVYNLDSY 150
            |:::.|:.:|.:...|:.||:  |.    :|.:.:.:|  |...|...:..|:.|||..||||:.
  Rat    86 KLMKRLNTEWSELENLILKDMSDGF----ISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTN 146

  Fly   151 AMTEGFIDD-KDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYHYDDNVSPEVLKIKLWN 214
            .:::|.:.. |.|:.  .:|::|..||.:.....||..:|.|:|.||...::.....|.|:.:.:
  Rat   147 TISKGNLPGVKHKSF--LTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKVSVLD 209

  Fly   215 YPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPKLKHLQSNPA------------ 267
            |      |..|....|...:|.....:||.::|.|......|...:::.|...
  Rat   210 Y------LSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSD 268

  Fly   268 KLTKPKK---------VFQLQKEICS----KRYRRKSGVLVCRYVDW--TPFLKLAPLKMEELSM 317
            :.|.|||         ..|..:.:|.    |...|:...|.|||.|.  .|...|||.|.|:...
  Rat   269 QKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWD 333

  Fly   318 KPYISIFYGFLGQKDIEVLKNVSRPKLQRIE-HLSGNCSCKIGNLSTSLH-------------DV 368
            ||.|..|:..:...:||::|::::|:|.|.. |     ..:.|.|:|:.:             .|
  Rat   334 KPRIIRFHDIISDAEIEIVKDLAKPRLSRATVH-----DPETGKLTTAQYRVSKSAWLSGYEDPV 393

  Fly   369 VRKVNELILGITGFPLKGNQMLEVINYGIAGNYNP-------EEPKIHNK-------ANAFIFLS 419
            |.::|..|..:||..:...:.|:|.|||:.|.|.|       :||....:       |....::|
  Rat   394 VSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMS 458

  Fly   420 NAGKGGEIVFPSRHLKVRPRKGSMLVWENL------KKSLIYHQCPILKGNMWVANKVLN 473
            :...||..|||.....|.|:||:.:.|.||      ..|..:..||:|.||.||:||.|:
  Rat   459 DVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	29/131 (22%)
		TPR repeat	169..197	CDD:276809	10/27 (37%)
		TPR repeat	202..245	CDD:276809	9/42 (21%)
		2OG-FeII_Oxy	<362..470	CDD:304390	39/140 (28%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	16/90 (18%)
		TPR	205..238		8/38 (21%)
		P4Hc	345..518	CDD:214780	50/177 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010