DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and p4ha1a

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	519	Identity:	128/519 - (24%)
Similarity:	218/519 - (42%)	Gaps:	96/519 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPRNL----IYG 88
            ||..|......||..::..|.:|:.|.|..:..|:::::...:.:.|..:....|...    :..
Zfish    24 DFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQWAEKLDALTATAVQDPEGFLGHPVNA 88

  Fly    89 YKVLRHLHNDWPQYFRLLKKDL--GLEQIAVSQMLLTQQ--PTSVDFEESMGAMHRLQTVYNLDS 149
            :|:::.|:.:|.:...|:.||:  |.    :|.:.:.:|  |...|...:..|:.|||..|.||:
Zfish    89 FKLMKRLNTEWGEVEDLVLKDMSDGF----ISNLTIQRQYFPNDEDQNGAAKALLRLQDTYKLDT 149

  Fly   150 YAMTEGFIDDKDKNI---RNWSADECLMLGLMYLFLKDYNQSENWLELALYHYDDNVSPEVLKIK 211
            ..::.|.:...:..:   ...:.::|..||.:.....||..:|.|:..||...|:..
Zfish   150 QTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYYHTELWMAQALKQLDEGE-------- 206

  Fly   212 LWNYPNLLESLVEANKGL----------GHYFEAKKYANELLSINPNH----------TYMLTQL 256
                    ||.||....|          |....|.:|...||::.|.|          .|.|.:.
Zfish   207 --------ESSVEIATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRALGNLKYFDYQLAKQ 263

  Fly   257 PKLKHLQSNPAKLTKPKKVFQLQKE----------ICS----KRYRRKSGVLVCRYVDWT--PFL 305
            .|.:..||...:..|.::....:||          :|.    |...|:...|.|||.:..  ||.
Zfish   264 KKAEKEQSTKEESKKEQETSDGKKEYLPEKRKYEKLCRGEGLKMTPRRQKHLFCRYFNGNRHPFY 328

  Fly   306 KLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRPKLQRI---EHLSGNCSCKIGNLSTSL-- 365
            .:.|:|.|:...:|.|..::..:.:::||.:|.:|:|:|:|.   ..::|........:|.|.
Zfish   329 TIGPVKQEDEWDRPRIIRYHEIITEQEIEKIKELSKPRLRRATISNPITGVLETAHYRISKSAWL 393

  Fly   366 ----HDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNP-------EEPKIHNK-------A 412
                |.||.::|:.|..|||..:|..:.|:|.|||:.|.|.|       :||....:       |
Zfish   394 AAYEHPVVDRINQRIEDITGLNVKTAEELQVANYGVGGQYEPHFDFGRKDEPDAFKELGTGNRIA 458

  Fly   413 NAFIFLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENL------KKSLIYHQCPILKGNMWVANK 470
            ....::|:...||..|||.....|:|.||:.:.|.||      ..|..:..||:|.||.||:||
Zfish   459 TWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	28/131 (21%)
		TPR repeat	169..197	CDD:276809	8/27 (30%)
		TPR repeat	202..245	CDD:276809	10/52 (19%)
		2OG-FeII_Oxy	<362..470	CDD:304390	43/133 (32%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	29/132 (22%)
		TPR repeat	172..207	CDD:276809	10/50 (20%)
		TPR repeat	212..242	CDD:276809	6/29 (21%)
		Fis1	218..262	CDD:304536	9/43 (21%)
		P4Hc	352..525	CDD:214780	53/171 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940