DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and P4HTM

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	493	Identity:	93/493 - (18%)
Similarity:	164/493 - (33%)	Gaps:	153/493 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 YFRLLKKDLGLEQIAVSQMLLTQQPTSVDFEESMGAMHRLQ---TVYNLDSYAMTEG-------- 155
            ||.:|...:.|....|..:||....::.|.....|..||.|   ....|......||
Human    60 YFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERK 124

  Fly   156 --FIDDKDKNIRNWSA-------------DECLML-------GL---MYLFLKDYNQSENWL--- 192
              .:.|:|..||..|.             :||.::       ||   ..|..::|.::.:.:
Human   125 VQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVS 189

  Fly   193 ELALYHYDDNVSPEVLKIK-----------LWNYPNLLESLVEANK----GLGHYFEAKKYANEL 242
            :|.|:...|......|:::           .|..|..::.:..|.|    |.| ....::::|
Human   190 QLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDG-VLSLQEFSN-- 251

  Fly   243 LSINPNHTYMLTQLPKLKHL--QSNPAKLTKPKKVFQLQKEICSKRYRRKSGVLVCRYVDWTPFL 305
            :.:...|.||.:...:...|  .|:...|.:.:....:.:.|..:..|               ..
Human   252 MDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLR---------------LT 301

  Fly   306 KLAPLKMEELSMKPYISIFYGFLGQKDIEVLKN-------VSRPKLQRIEHLSGNCSCKIGNLST 363
            :|:| ::.||| :|...:.||..|.....|...       .|..||...|.:....||:..:.:.
Human   302 RLSP-EIVELS-EPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNW 364

  Fly   364 SLHDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNP-----------EEPKI--------- 408
            .|..::|         .|.|:...|...|   |:.....|           |.|::
Human   365 GLPSILR---------PGTPMTQAQPCTV---GVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLP 417

  Fly   409 HNKANAFIFLSNAGKGGEIVFP----------------------SRH-----LKVRPRKGSMLVW 446
            ::......:|:|...|||.|||                      .||     |:|:|::|:.:.|
Human   418 YSYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFW 482

  Fly   447 EN-----------LKKSLIYHQCPILKGNMWVANKVLN 473
            .|           :....::..|.:.:|..|:||..:|
Human   483 YNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWIN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	15/67 (22%)
		TPR repeat	169..197	CDD:276809	7/53 (13%)
		TPR repeat	202..245	CDD:276809	8/57 (14%)
		2OG-FeII_Oxy	<362..470	CDD:304390	30/165 (18%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111		5/21 (24%)
		EF-hand_7	192..252	CDD:290234	10/62 (16%)
		EFh	194..252	CDD:238008	9/60 (15%)
		P4Hc	246..519	CDD:214780	56/303 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840