DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and P4HA1

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_000908.2	Gene:	P4HA1 / 5033	HGNCID:	8546	Length:	534	Species:	Homo sapiens

Alignment Length:	546	Identity:	134/546 - (24%)
Similarity:	233/546 - (42%)	Gaps:	101/546 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFHFVVVTACLGFQVKGEVVSAPESY---DFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQ 62
            |:::.:::...|           |:|.   .|..|......|:..::..|.:|:.|.|..:..|:
Human     1 MIWYILIIGILL-----------PQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLE 54

  Fly    63 KIRRAIRQSEELLKSTKTSPRNL----IYGYKVLRHLHNDWPQYFRLLKKDL--GLEQIAVSQML 121
            :|::...:.:.|..:....|...    :..:|:::.|:.:|.:...|:.||:  |.    :|.:.
Human    55 QIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGF----ISNLT 115

  Fly   122 LTQQ--PTSVDFEESMGAMHRLQTVYNLDSYAMTEGFIDD-KDKNIRNWSADECLMLGLMYLFLK 183
            :.:|  |...|...:..|:.|||..||||:..:::|.:.. |.|:.  .:|::|..||.:.....
Human   116 IQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSF--LTAEDCFELGKVAYTEA 178

  Fly   184 DYNQSENWLELALYHYDDNVSPEVLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPN 248
            ||..:|.|:|.||...|:.....:.|:.:.:|      |..|....|...:|.....:||.::|.
Human   179 DYYHTELWMEQALRQLDEGEISTIDKVSVLDY------LSYAVYQQGDLDKALLLTKKLLELDPE 237

  Fly   249 HTYMLTQLPKLKHLQSNPAKLTK------------PKK---------VFQLQKEICS----KRYR 288
            |......|...:::.:....:.|            |||         ..|..:.:|.    |...
Human   238 HQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTP 302

  Fly   289 RKSGVLVCRYVDW--TPFLKLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRPKLQRIE-HL 350
            |:...|.|||.|.  .|...|||.|.|:...||.|..|:..:...:||::|::::|:|.|.. |
Human   303 RRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVH- 366

  Fly   351 SGNCSCKIGNLSTSLH-------------DVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYN 402
                ..:.|.|:|:.:             .||.::|..|..:||..:...:.|:|.|||:.|.|.
Human   367 ----DPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYE 427

  Fly   403 P-------EEPKIHNK-------ANAFIFLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENL---- 449
            |       :||....:       |....::|:...||..|||.....|.|:||:.:.|.||
Human   428 PHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASG 492

  Fly   450 --KKSLIYHQCPILKGNMWVANKVLN 473
              ..|..:..||:|.||.||:||.|:
Human   493 EGDYSTRHAACPVLVGNKWVSNKWLH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	29/131 (22%)
		TPR repeat	169..197	CDD:276809	10/27 (37%)
		TPR repeat	202..245	CDD:276809	8/42 (19%)
		2OG-FeII_Oxy	<362..470	CDD:304390	39/140 (28%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	16/90 (18%)
		TPR	205..238		8/38 (21%)
		P4Hc	345..518	CDD:214780	50/177 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010