DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and p4ha2

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	131/533 - (24%)
Similarity:	234/533 - (43%)	Gaps:	91/533 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVVTACLGFQVKGEVVSAPESYDFAISSESQLSLLKLKETHVNNLQSYKKVLK---KHLQKIRRA 67
            ::::.|..::|:.||          .:|..|::.|..:|..:  |||.|:.::   :.|.||:|.
Frog     9 ILLSLCCIWEVQTEV----------FTSTGQMTDLIFRERDL--LQSLKEYIREEEERLSKIKRW 61

  Fly    68 IRQSEELLKSTKTSPRNL----IYGYKVLRHLHNDWPQYFRLLKKDLGLEQIAVSQMLLTQQPTS 128
            ..:.:||...:...|...    :..||:::..:.||.....|:.:|.....||.........||.
Frog    62 ASEVDELSSRSTADPEGYLGHPVNAYKLVKRFNTDWSSLENLVLQDSAKGFIANFTFQREYFPTE 126

  Fly   129 VDFEESMGAMHRLQTVYNLDSYAMTEGFIDDKDKNIRNWSADECLMLGLMYLFLKDYNQSENWLE 193
            .|...:..|:.|:|..|.||...:.:|.:...: .|.:.|||:...:|.:.....||..:..|::
Frog   127 EDETGAARALMRIQDTYKLDPDVIAKGKLPGTN-YISSLSADDSFGMGKIAYHDGDYYHTVLWMQ 190

  Fly   194 LALYHYDDNVSPEVLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPK 258
            .||...|:.....|.|:.:.:|  |..::.:    ||....|.:....||:::|||...:..|..
Frog   191 QALKQMDEGEDAVVNKVDVLDY--LSYTVFQ----LGDVPRALELTKRLLALDPNHDRAVNNLKY 249

  Fly   259 LKHLQ------------SNPAKLTKPKKVF----------QLQKEIC--------SKRYRRKSGV 293
            .:.:|            :|....|:...|:          .:.:.:|        .:|.||
Frog   250 FEKMQEKQKAELKQNESTNTESATRQPGVYSRPLDYLPERDVYEALCRGEGVKMNPRRQRR---- 310

  Fly   294 LVCRYVDW--TPFLKLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRPKLQRI---EHLSGN 353
            |.|||.:.  :|:|.|:|:|:|:....|.|..:...|..::|..:|.:::|||.|.   :..:|.
Frog   311 LFCRYHNGNRSPYLILSPVKVEDEWDSPRIVRYLNALSDEEIAKIKELAKPKLARATVRDPKTGV 375

  Fly   354 CSCKIGNLSTSL------HDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNP-------EE 405
            .|.....:|.|.      ..|:.:||..:..|||..:...::|:|.|||:.|.|.|       :|
Frog   376 LSVANYRVSKSAWLEENDDPVIARVNLRMQAITGLTVDTAELLQVANYGMGGQYEPHFDFSRKDE 440

  Fly   406 PKIH------NKANAFI-FLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENLKKS------LIYHQ 457
            |.:.      |:...|: ::|:...||..|||.....:.|:||:.:.|.||.:|      ..:..
Frog   441 PDVFKRLGTGNRVATFLNYMSDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAA 505

  Fly   458 CPILKGNMWVANK 470
            ||:|.|:.||:||
Frog   506 CPVLVGSKWVSNK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	33/130 (25%)
		TPR repeat	169..197	CDD:276809	7/27 (26%)
		TPR repeat	202..245	CDD:276809	9/42 (21%)
		2OG-FeII_Oxy	<362..470	CDD:304390	39/133 (29%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	20/87 (23%)
		TPR repeat	166..201	CDD:276809	9/34 (26%)
		TPR repeat	206..236	CDD:276809	8/35 (23%)
		P4Hc	348..521	CDD:214780	49/171 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000