DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and CG31021

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_733392.2	Gene:	CG31021 / 43638	FlyBaseID:	FBgn0051021	Length:	453	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	109/474 - (22%)
Similarity:	203/474 - (42%)	Gaps:	66/474 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPR----NLIYGYKVLRHLHNDW 99
            :|.|:...:.|::.|.:.|::.:..|...:......::.....|.    |.:..::::||:|.||
  Fly     1 MLNLERNLLQNMRDYAEKLEEKIDLINNYVEDYNVDIEDANEDPEKYLSNPLNSFRLIRHMHQDW 65

  Fly   100 PQYFRLLKKDLGLEQIAVSQMLLTQQPTSVDFEESMGAMHRLQTVYNLDSYAMTEGFIDDKDKNI 164
            ..:...::..:..|.:...:.||.|.|....|.::..::|.|...|   .|...:....|:..:.
  Fly    66 VGWQVYMEDLVAPEAVQKVESLLPQLPQKEAFRKAARSVHSLTQFY---GYEPADLVAKDERSSS 127

  Fly   165 RNWSADECLMLGLMYLFLKDYNQSENWLELALYHYD-----DNVSPEVLKIKLWN-YPNLLESLV 223
            .:.|..:|..|||.....:||..:..||::|.::|.     |..:|  |....|. |.:|..:|:
  Fly   128 LHLSPLDCYHLGLELYEEQDYLGAAKWLQVAAHNYTLSRHRDLFNP--LGAPRWQVYRDLGRTLL 190

  Fly   224 EANKGLGHYFEAKKYANELLSINPNHTYMLTQLPKLK------------HLQSNPAKLTKPKKVF 276
            :.|:...  ::|.:.|   |.:|..:.:::.:..:::            .||..|..|.|
  Fly   191 KLNRQCA--YDAYESA---LRLNSQNVHLMKEAGQMELFSLRDPMEPILDLQPKPTVLEK----- 245

  Fly   277 QLQKEICSKRYRRKSGVLVCRYVDWT-PFLKLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNVS 340
                 .|.....|..|.|.|...||. .||..||:|.|:|...|:|.::.|.:.:::|..::|..
  Fly   246 -----YCRGEVPRHQGRLTCELNDWVHSFLAYAPIKFEDLQQDPFIILYPGSIYEQEIRHVENAY 305

  Fly   341 R--PKLQRIEHLSGNCSCKIGNLSTSLHDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNP 403
            .  |...|.|...|...|.|   |.....|::::||.||.:.|.. |......::.|.....:.|
  Fly   306 ERCPPNDRFELKLGISGCSI---SDGYSPVLKRINERILDMAGVE-KTWDTFYIVEYAQLAPFEP 366

  Fly   404 --------EEPKIH------NKANAFIFLSNAGKGGEIVFPSRHLKVRPRKGSMLV-WENLKKSL 453
                    :.||::      .:|...|||.:...||....|:..:.|:|::|::|: :||.:.|.
  Fly   367 FKLFRNSTKFPKLNLMNFEDVEAKVIIFLKDVTLGGAFTMPNGDILVQPKRGNVLITFENEEHST 431

  Fly   454 IYHQCPILKGNMWVANKVL 472
            ..  |||::|...|..|.:
  Fly   432 TI--CPIIEGTGLVMIKFI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	23/121 (19%)
		TPR repeat	169..197	CDD:276809	9/27 (33%)
		TPR repeat	202..245	CDD:276809	10/43 (23%)
		2OG-FeII_Oxy	<362..470	CDD:304390	31/122 (25%)
CG31021	NP_733392.2	P4Ha_N	1..119	CDD:285528	23/120 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.080