DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and CG31371

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	122/512 - (23%)
Similarity:	200/512 - (39%)	Gaps:	120/512 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VVSAPESYDFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRR---AIRQSEELLKSTKTS 81
            :|.:....:||...|...:||..:...::.|:.|.:.|::.|::|||   ||.:....:.|.:..
  Fly    16 LVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEEIHSQVDSVEEY 80

  Fly    82 PRNLIYGYKVLRHLHNDWPQYFRLLKKDLGLEQIA-----------VSQMLLTQQPTSVDFEESM 135
            ..|.:..:.:|:...:.||          ||||.|           :|...|| .|:..|:|||:
  Fly    81 MGNPLNVFGILKRFESVWP----------GLEQKANATLEMVFGERLSDRQLT-LPSEEDYEESL 134

  Fly   136 GAMHRLQTVYNLDSYAMTEGFIDD-KDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYHY 199
            ..:..||:||.|||.:::.|.::. |..:..:|.  :||.:...    .|:..:..|||.||...
  Fly   135 NHLLHLQSVYELDSNSLSLGVVNGFKLGSSMSWG--DCLEVARK----SDFPVARFWLESALEKL 193

  Fly   200 ---DDNVSPEVLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPKL-- 259
               .:| |.|..:.:.....::||:.:......|....|...|.|||.:.|.:..:.....|:
  Fly   194 PSASEN-STESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQGIQKAKRKIEK 257

  Fly   260 ----KHLQSNPAKLTKPKKVFQLQK--------EIC---------SKRYRRKSGVLVCRYVDWTP 303
                |.|.....:.:|.||  |:.|        |||         ..|:..      |:....:|
  Fly   258 AMAKKELPKGRGQKSKAKK--QISKSTEQLLIEEICRGAKQQVTTGSRFNH------CQLDGSSP 314

  Fly   304 FLKLAPLKMEELSMKPYISIFYGFLGQKDIEVL----------KNVSRPKLQRIEHLSGNCSCKI 358
            :|.|.|.::|.:|..|||.:.:..|..|:...|          |.||...|:    ||.....|:
  Fly   315 WLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDEEEDTKGVSYQSLK----LSKLAQKKL 375

  Fly   359 GNLSTSLHDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNPEE--------PKIHNKANAF 415
            |.:|.                    |.|.::||:..:  .|..:..|        .::.:.|...
  Fly   376 GRISR--------------------LLGLEILELDPW--TGRRHGHEHITKLEHSSELKHVARLM 418

  Fly   416 IFLSNAGKGGEIVFPSRHLKVRPRKGSMLVWE-----NLKKSLIYHQ----CPILKG 463
            :.|...|.||.:|||...|.|...:||:|.|.     .......|..    ||:|.|
  Fly   419 LNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSSSEWDYRSGQAICPVLLG 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	38/137 (28%)
		TPR repeat	169..197	CDD:276809	7/27 (26%)
		TPR repeat	202..245	CDD:276809	11/42 (26%)
		2OG-FeII_Oxy	<362..470	CDD:304390	26/119 (22%)
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	38/136 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940