DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and CG11828

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	126/489 - (25%)
Similarity:	210/489 - (42%)	Gaps:	104/489 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSP-------RNLIYGYKVLRHL 95
            |||::::..:..::.|...|:..:..:|..   .||.:......|       .|.:..:.::|..
  Fly     3 SLLQIEDELIGYMRQYAMELQHKVNTMRTF---QEEWMTRRALGPADPTSYVANPLISFPLMRRT 64

  Fly    96 HNDWPQYFRLLKK-----------DLGLEQIAVSQMLLTQQPTSVDFEESMGAMHRLQTVYNLDS 149
            :.|.|:...|.::           |..|..|           :.|:.|.::..|.|.|.||.:|.
  Fly    65 YTDVPKLLELAREEFKPGPFQKFIDYDLSSI-----------SDVELETAVTGMLRFQGVYGMDE 118

  Fly   150 YAMTEGFIDDKDKNIRNWSADECLMLGLMYLFLKDYNQSE---NWLELALYHYDDNVSP------ 205
            ..|..|.:..|..|.| .||.:||.:.   ..|::.::.:   .|.::|:..|::.:.|
  Fly   119 SEMANGKLHGKQYNSR-MSAADCLAVA---THLENVDKGKLACKWFKVAIDQYEEKLDPVNRLLQ 179

  Fly   206 -------EVLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPKLKHLQ 263
                   |.|.:.|....:|..|.......:|.   |.|..|..|:               |||:
  Fly   180 TGRSQIYEKLGLTLLAMHDLPASQAAFRDSIGW---ASKEDNTDLA---------------KHLK 226

  Fly   264 SNPAKLTKPKKVFQLQKEICSKRYRRKSGVLVCRYV-DWTPFLKLAPLKMEELSMKPYISIFYGF 327
            ...|.:.......:.:..:.||.|.|      |||: |.:|||::||:|:|:|:::|::.:|:..
  Fly   227 DKLAHMFVHVDNCRGKNLLPSKSYLR------CRYLRDGSPFLRMAPVKLEQLNIEPFVGLFHDA 285

  Fly   328 LG---QKDIEVLKNVSRPKLQRIEHLSGNCSCKIGNLSTSLHDVVRKVNELILGITGFPLKGNQM 389
            :.   |||:..|.:      .|:||...:.|.....:.|:..|.||::::.|..||||.|:.::.
  Fly   286 ISPAEQKDLLHLTD------SRLEHRKKDSSSVEAKVDTNASDHVRRIHQRIEDITGFDLEESEP 344

  Fly   390 LEVINYGIAGN-------YNPEE-----PKIHNKANAFIFLSNAGKGGEIVFPSRHLKVRPRKGS 442
            |.|.||||.|.       ..|:|     ||.:..|:|..:||:...||...||......:||:||
  Fly   345 LTVSNYGIGGQDFIHLDCEQPKEFIGYYPKEYRSASAMFYLSDVQMGGYASFPDLGFGFKPRRGS 409

  Fly   443 MLVWENLKKS------LIYHQCPILKGNMWVANK 470
            .|||.|...|      .:...||:|.||.|||.|
  Fly   410 ALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKK 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	27/136 (20%)
		TPR repeat	169..197	CDD:276809	6/30 (20%)
		TPR repeat	202..245	CDD:276809	11/55 (20%)
		2OG-FeII_Oxy	<362..470	CDD:304390	46/125 (37%)
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	27/136 (20%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	55/163 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461871
Domainoid	1	1.000	59	1.000	Domainoid score	I3907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990