DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4174 and p4ha2

DIOPT Version :9

Sequence 1:NP_001034031.2 Gene:CG4174 / 40023 FlyBaseID:FBgn0036793 Length:473 Species:Drosophila melanogaster
Sequence 2:XP_005173949.1 Gene:p4ha2 / 373132 ZFINID:ZDB-GENE-030827-1 Length:542 Species:Danio rerio


Alignment Length:536 Identity:132/536 - (24%)
Similarity:235/536 - (43%) Gaps:86/536 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VTACLGFQVKGEVVSAPESYDFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSE 72
            :.|.|.|.:.....|:|...:...|.....:|:..:...|.:|:.|.:..::.|:.:|....:.:
Zfish     1 MAAFLVFLLSTLSFSSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLD 65

  Fly    73 ELLKSTKTSPRNL----IYGYKVLRHLHNDWPQYFRLLKKDL--GLEQIAVSQMLLTQQ--PTSV 129
            :|.:::.:.|...    :..||:::.|:.:|.:...|:.:|.  |.    :|.|.:.:|  |...
Zfish    66 KLTRTSTSDPEGFLAHPVNAYKLMKRLNTEWSELESLVLQDPSDGF----ISNMSVHRQYFPDEE 126

  Fly   130 DFEESMGAMHRLQTVYNLDSYAMTEGFIDDKDKN--IRN---WSADECLMLGLMYLFLKDYNQSE 189
            |.:.:..|:.|||..|.||:.:.::|.:..:.::  :|.   .:.|:|..:|.|.....||..|.
Zfish   127 DEKGAAKALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSV 191

  Fly   190 NWLELALYHYDDNVSPEVLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYM-- 252
            .|::.:|...|.....:..|..:.:|  |..|:.:    :|....|.:....||:|:|:|...  
Zfish   192 LWMQQSLRQMDSGEEAKTPKADVLDY--LSYSVYQ----MGDLPRAIELTRRLLAIDPSHQRAGG 250

  Fly   253 -LTQLPKL--KHLQSN-----------PAKL---TKPKKVF---QLQKEICS----KRYRRKSGV 293
             |....:|  |.||.:           |.:|   .:||...   :..:.:|.    |...::...
Zfish   251 NLRYFERLLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTTKRQSR 315

  Fly   294 LVCRYVDW--TPFLKLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRPKLQR---------- 346
            |.|||.|.  .|.|.|.|:|.|:....|:|..|...|..::|:.:|.::.|||.|          
Zfish   316 LFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDPKTGV 380

  Fly   347 --IEHLSGNCSCKIGNLSTSLHDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNP------ 403
              :.|...:   |...|......|:.:||:.|..|||..:...::|:|.|||:.|.|.|      
Zfish   381 LTVAHYRVS---KSAWLEGEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDFSR 442

  Fly   404 -EEPKIH------NKANAFI-FLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENLKKS------LI 454
             :||...      |:...:: ::|:...||..|||.....|.||||:.:.|.||.:|      ..
Zfish   443 KDEPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGDYRTR 507

  Fly   455 YHQCPILKGNMWVANK 470
            :..||:|.|:.||:||
Zfish   508 HAACPVLVGSKWVSNK 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4174NP_001034031.2 P4Ha_N 33..157 CDD:285528 28/131 (21%)
TPR repeat 169..197 CDD:276809 8/27 (30%)
TPR repeat 202..245 CDD:276809 8/42 (19%)
2OG-FeII_Oxy <362..470 CDD:304390 39/127 (31%)
p4ha2XP_005173949.1 P4Ha_N 25..154 CDD:285528 29/132 (22%)
P4Hc 353..526 CDD:214780 50/174 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000199
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10869
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

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