Protein Alignment CG4174 and p4ha2

DIOPT Version :10

• Sequence 1: NP_730342.2
• Gene: CG4174 / 40023
• FlyBaseID: FBgn0036793
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: XP_005173949.1
• Gene: p4ha2 / 373132
• ZFINID: ZDB-GENE-030827-1
• Length: 542
• Species: Danio rerio
• Alignment Length: 536
• Identity: 132/536 - (24%)
• Similarity: 235/536 - (43%)
• Gaps: 86/536 - (16%)

  Fly     8 VTACLGFQVKGEVVSAPESYDFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSE 72
            :.|.|.|.:.....|:|...:...|.....:|:..:...|.:|:.|.:..::.|:.:|....:.:
Zfish     1 MAAFLVFLLSTLSFSSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLD 65

  Fly    73 ELLKSTKTSPRNL----IYGYKVLRHLHNDWPQYFRLLKKDL--GLEQIAVSQMLLTQQ--PTSV 129
            :|.:::.:.|...    :..||:::.|:.:|.:...|:.:|.  |.    :|.|.:.:|  |...
Zfish    66 KLTRTSTSDPEGFLAHPVNAYKLMKRLNTEWSELESLVLQDPSDGF----ISNMSVHRQYFPDEE 126

  Fly   130 DFEESMGAMHRLQTVYNLDSYAMTEGFIDDKDKN--IRN---WSADECLMLGLMYLFLKDYNQSE 189
            |.:.:..|:.|||..|.||:.:.::|.:..:.::  :|.   .:.|:|..:|.|.....||..|.
Zfish   127 DEKGAAKALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSV 191

  Fly   190 NWLELALYHYDDNVSPEVLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYM-- 252
            .|::.:|...|.....:..|..:.:|  |..|:.:    :|....|.:....||:|:|:|...
Zfish   192 LWMQQSLRQMDSGEEAKTPKADVLDY--LSYSVYQ----MGDLPRAIELTRRLLAIDPSHQRAGG 250

  Fly   253 -LTQLPKL--KHLQSN-----------PAKL---TKPKKVF---QLQKEICS----KRYRRKSGV 293
             |....:|  |.||.:           |.:|   .:||...   :..:.:|.    |...::...
Zfish   251 NLRYFERLLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTTKRQSR 315

  Fly   294 LVCRYVDW--TPFLKLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRPKLQR---------- 346
            |.|||.|.  .|.|.|.|:|.|:....|:|..|...|..::|:.:|.::.|||.|
Zfish   316 LFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDPKTGV 380

  Fly   347 --IEHLSGNCSCKIGNLSTSLHDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNP------ 403
              :.|...:   |...|......|:.:||:.|..|||..:...::|:|.|||:.|.|.|
Zfish   381 LTVAHYRVS---KSAWLEGEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDFSR 442

  Fly   404 -EEPKIH------NKANAFI-FLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENLKKS------LI 454
             :||...      |:...:: ::|:...||..|||.....|.||||:.:.|.||.:|      ..
Zfish   443 KDEPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGDYRTR 507

  Fly   455 YHQCPILKGNMWVANK 470
            :..||:|.|:.||:||
Zfish   508 HAACPVLVGSKWVSNK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_730342.2	P4Ha_N	33..159	CDD:462433	28/133 (21%)
		TPR repeat	169..197	CDD:276809	8/27 (30%)
		TPR repeat	202..245	CDD:276809	8/42 (19%)
		PLN00052	311..>470	CDD:177683	54/190 (28%)
p4ha2	XP_005173949.1	P4Ha_N	25..156	CDD:462433	29/134 (22%)
		NrfG	177..280	CDD:443378	25/108 (23%)
		P4Hc	353..526	CDD:214780	50/174 (29%)