DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and P4ha2

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	131/515 - (25%)
Similarity:	211/515 - (40%)	Gaps:	92/515 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPRNL----IYG 88
            :|..|......|:..::..|.:|:.|....:..|.||:....:.|.|...:...|...    :..
  Rat    22 EFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNA 86

  Fly    89 YKVLRHLHNDWPQYFRLLKKDLGLEQIA---VSQMLLTQQ--PTSVDFEESMGAMHRLQTVYNLD 148
            ||:::.|:.|||..     .||.|:..|   |:.:.:.:|  ||..|...:..|:.|||..|.||
  Rat    87 YKLVKRLNTDWPAL-----GDLVLQDAAAGFVANLSVQRQFFPTDEDESGAARALMRLQDTYKLD 146

  Fly   149 SYAMTEGFIDDKDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYHYDDNVSPEVLKIKLW 213
            ...::.|.:.. .|.....|.|:|..:|.......||..:..|:|..|...|......|.|..:.
  Rat   147 PDMISRGELPG-TKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATVTKSLVL 210

  Fly   214 NYPNLLESLVEANKGLGHYFEAKKYANELLSINPNH----------TYMLTQ------------- 255
            :|      |..|...||....|.:....|||::|:|          ..:|.:
  Rat   211 DY------LSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAG 269

  Fly   256 LPKLKHLQSNPAKLTKPKKVFQLQKEICS----KRYRRKSGVLVCRY--VDWTPFLKLAPLKMEE 314
            |...::|...|......:.|::   .:|.    |...|:...|.|||  .:..|.|.:||.|.|:
  Rat   270 LASQENLYERPVDYLPERDVYE---SLCRGEGIKMTPRRQKRLFCRYHHGNRVPQLLIAPFKEED 331

  Fly   315 LSMKPYISIFYGFLGQKDIEVLKNVSRPKLQRI---EHLSG---NCSCKIGNLSTSLHD---VVR 370
            ....|:|..:|..:..::||.:|.:::|||.|.   :..:|   ..|.::...|....|   ||.
  Rat   332 EWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVA 396

  Fly   371 KVNELILGITGFPLKGNQMLEVINYGIAGNYNPEEPKIH------------------NKANAFI- 416
            :||..:..|||..:|..::|:|.|||:.|.|.|     |                  |:...|:
  Rat   397 RVNRRMQHITGLTVKTAELLQVANYGMGGQYEP-----HFDFSRSDERDAFKRLGTGNRVATFLN 456

  Fly   417 FLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENLKKS------LIYHQCPILKGNMWVANK 470
            ::|:...||..|||.....:.|:||:.:.|.||.:|      ..:..||:|.|..||:||
  Rat   457 YMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	33/132 (25%)
		TPR repeat	169..197	CDD:276809	7/27 (26%)
		TPR repeat	202..245	CDD:276809	10/42 (24%)
		2OG-FeII_Oxy	<362..470	CDD:304390	40/135 (30%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	17/81 (21%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	51/176 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010