DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and CG31016

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	134/519 - (25%)
Similarity:	212/519 - (40%)	Gaps:	105/519 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ESY----DFAISSESQLSLLKLKETHVNNLQSY-----------KKVLKKHLQKIRRAIRQSEEL 74
            |.|    ::.||.|.::.||:.....:..|.||           |:::|:..|.:.:|..:.||.
  Fly    20 EGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQPLEKAKNREEEY 84

  Fly    75 LKSTKTSPRNLIYGYKVLRHLHNDWPQYFRLLKKDLGLEQIAVSQMLLTQQPTSVDFEESMGAMH 139
            |.       |.|....::|.:|.||.:..:||||.:|.|:||:.:.:....|...|..|:..||.
  Fly    85 LS-------NPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDLMEANQAMF 142

  Fly   140 RLQTVYNLDSYAMTEGFIDDKDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELA--------- 195
            |:...|:|:...::.|:||..... ...||.:|..:|........|..:..||..|
  Fly   143 RILHTYDLEPKDVSAGWIDGVQYG-GKMSASDCFTMGTFSFMAGSYQIASKWLSAAKDLLVDQPR 206

  Fly   196 LYHYDDNVSPEVLKIKLWNYPNLL-ESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPK- 258
            .||       ||:.|...:...|| .||:.:..        ...|.::|.    ..:|..:...
  Fly   207 KYH-------EVMGITKADVTLLLARSLIASGN--------VSIATDMLM----RDFMFGEAGSA 252

  Fly   259 -LKHLQSNPAKLTKPKKVFQLQ--------KEICSKRYRRKSGV-----LVCRY-VDWTPFLKLA 308
             ..|...|     |||....|:        .::|....||:.|.     |.||| ...|||||||
  Fly   253 LTVHFLRN-----KPKPSINLESWESDESFNQLCRSSSRRQMGESKPSRLHCRYNTITTPFLKLA 312

  Fly   309 PLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRP-----KLQRIEHLSGNCSCKIG--------- 359
            |.:|||||:.||:..::..|...:||.||.:.:|     |:.|:|..|........
  Fly   313 PFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSDEIDPSRSADGAWLPHQ 377

  Fly   360 NLSTSLHDVVRKVNELILGITGFPLKGNQMLEVINYGIAGNYNPEEPKIHNK-----------AN 413
            |:.....:|:.::...|..:||...:....::.:.||..|::.|.....::|           |.
  Fly   378 NIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNSKTFSLETVGDRIAT 442

  Fly   414 AFIFLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENL-KKSLIYH------QCPILKGNMWVANK 470
            ...:|:|...||..|||..:|.|..:|||.|.|.|: :||..|.      .||::.|...|..:
  Fly   443 VLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLISGTKLVMTR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	36/134 (27%)
		TPR repeat	169..197	CDD:276809	7/36 (19%)
		TPR repeat	202..245	CDD:276809	9/43 (21%)
		2OG-FeII_Oxy	<362..470	CDD:304390	32/125 (26%)
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	37/135 (27%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	42/174 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000