DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and CG32201

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	130/519 - (25%)
Similarity:	227/519 - (43%)	Gaps:	85/519 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LGFQVKGEVVSAPESYD----FAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQ-S 71
            |||.|....|...|..:    ::.|:...|.|||::|...:||.:....|.:..:.:|..:.. .
  Fly    12 LGFAVLNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYLSSVG 76

  Fly    72 EELLKSTKTSPR---NLIYGYKVLRHLHNDWPQYFRLLKKDLGLEQIAVSQMLLTQQPTSVDFEE 133
            .||.:|.....:   |.|..:.:||..|.|.|::....|:.:|....::...|:...|..||...
  Fly    77 YELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQSILVDLVKMVPNDVDMLS 141

  Fly   134 SMGAMHRLQTVYNLDSYAMTEGFIDDKDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYH 198
            :|..:.|::.:|:|....:.:|.:.....|::....|...|...||. ..||..:..|..:|...
  Fly   142 AMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQ-QSDYQTAAKWYRIACKR 205

  Fly   199 YDDNVSPEVLKIKLWNYPN------LLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLP 257
            ..:|  ||.|.|::...|:      .::||.:......   |..|...|        .:::.|..
  Fly   206 ELEN--PEQLFIQILGDPSEHLHRQYIKSLFKYGSTTS---EPSKSIEE--------AFIMVQAS 257

  Fly   258 KLKHLQSNPAKLTKPKKVFQLQKEI-------------CSKRYRRKSGVLVCRYVDW-TPFLKLA 308
            : :.|.:..:.|.:|:...:::|::             |...||:|:. |||||... ..||:||
  Fly   258 Q-EELDNIMSDLNEPQNDVEVEKDLYQVKRSPSNCELGCRGLYRQKTN-LVCRYKSTANTFLRLA 320

  Fly   309 PLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRPKLQRIEHLSGNCSCKIGNLSTSLHDVV---- 369
            |||:||:|:.|::::::..|...:|..||.      |.:..::|..|.:.|   |.:.|.|
  Fly   321 PLKLEEISLDPFMAMYHEVLYDSEIRELKG------QSMNMVNGYASQRNG---TEIRDTVVRYD 376

  Fly   370 ---------RKVNELILGITGFPLKGNQMLEVINYGIAGNYNP---------EEPKI----HNKA 412
                     .::|:.|:.:|||....::.|::.|||:...:.|         |.|.|    ...|
  Fly   377 WWSNTSLVRERINQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFDYSSDGFETPNITTLGDRLA 441

  Fly   413 NAFIFLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENL----KKSL--IYHQCPILKGNMWVANK 470
            :...:.|...:||..|||..::.|.|:|||||.|.||    |..:  ::..||:|.|:.|...|
  Fly   442 SILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	30/127 (24%)
		TPR repeat	169..197	CDD:276809	8/27 (30%)
		TPR repeat	202..245	CDD:276809	11/48 (23%)
		2OG-FeII_Oxy	<362..470	CDD:304390	39/139 (28%)
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	31/128 (24%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	47/174 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000