Protein Alignment CG4174 and P4HA3

DIOPT Version :10

• Sequence 1: NP_730342.2
• Gene: CG4174 / 40023
• FlyBaseID: FBgn0036793
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 125/543 - (23%)
• Similarity: 210/543 - (38%)
• Gaps: 159/543 - (29%)

  Fly    17 KGEVVSAPESYDFAISSESQL-----SLLKLKETHVNNL-QSYKKVLKKHLQKIRRAIRQSEELL 75
            :|:..||..|...|::.|.:|     ..|:.:|..:.:| :.|.|||..|
Human    27 RGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDKVLSLH--------------- 76

  Fly    76 KSTKTSPRNLIYGYKVLRHLHNDWPQYFRLLK--------KDLGLEQIAVSQMLLTQQPTSVDFE 132
            :.:.|...|.:..:.:::.|.:||......|:        || |.|:  |.|.|    |...|.|
Human    77 EDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKD-GYEK--VEQDL----PAFEDLE 134

  Fly   133 ESMGAMHRLQTVYNLDSYAMTEGF--------IDD--KDKNIRNWSADECLMLGLMYLFLKDYNQ 187
            .:..|:.|||.||.|:...:..|.        |.|  ..|.:.:.:.|:|..:|.:...:.||..
Human   135 GAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYH 199

  Fly   188 SENWLELAL---------YHYDDNVSPEVLKIKLWNYPNLLESLVEANKGLGHYFEA-------- 235
            :..|||.|:         :..:|..|.|          :.|:.|..|      ||.|
Human   200 AIPWLEEAVSLFRGSYGEWKTEDEASLE----------DALDHLAFA------YFRAGNVSCALS 248

  Fly   236 ------------KKYA------NELLSINPNHTY--MLTQLPKLKHLQSNPA------KLTKPKK 274
                        |:.|      ..||:.:|||..  .:.|.|.:.|||:...      .|.....
Human   249 LSREFLLYSPDNKRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPT 313

  Fly   275 VFQLQKEICSKRYRRKSGVLVCRYVDWTPFLKLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNV 339
            ::|:....||  |...|..          :|.|.|::.|.:.::|||::::.|:...:.:.::.:
Human   314 LYQIPSLYCS--YETNSNA----------YLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIREL 366

  Fly   340 SRPKLQRIEHLSGNCSCKIG---NLSTSLHDVVR----KVNELILGITGFPLKG--NQMLEVINY 395
            :.|.|||....||....::.   :.|..|.|.|.    .:|..|..:||..::.  .:.|:|:||
Human   367 AEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNY 431

  Fly   396 GIAGNY--------NPEEP----KIHNKANAF-IFLSNAGKGGEIVFPSRHLKVRPRKGSMLVWE 447
            ||.|:|        :|..|    |..|:...| |:||:...||...|               ::.
Human   432 GIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAF---------------IYA 481

  Fly   448 NLKKSLIYH----QCP-ILKGNM 465
            ||...::.|    .|. ::||.:
Human   482 NLSVPVVRHCFGGTCTGVVKGTV 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_730342.2	P4Ha_N	33..159	CDD:462433	35/147 (24%)
		TPR repeat	169..197	CDD:276809	9/36 (25%)
		TPR repeat	202..245	CDD:276809	12/68 (18%)
		PLN00052	311..>470	CDD:177683	44/182 (24%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433	31/123 (25%)
		BepA	<188..289	CDD:443813	23/116 (20%)
		P4Hc	356..>478	CDD:214780	32/121 (26%)