Protein Alignment CG4174 and P4ha1

DIOPT Version :10

• Sequence 1: NP_730342.2
• Gene: CG4174 / 40023
• FlyBaseID: FBgn0036793
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_035160.1
• Gene: P4ha1 / 18451
• MGIID: 97463
• Length: 534
• Species: Mus musculus
• Alignment Length: 511
• Identity: 131/511 - (25%)
• Similarity: 222/511 - (43%)
• Gaps: 79/511 - (15%)

  Fly    29 FAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPRNL----IYGY 89
            |..|......|:..::..|.:|:.|.|..:..|::|::...:.:.|..:....|...    :..:
Mouse    21 FFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAF 85

  Fly    90 KVLRHLHNDWPQYFRLLKKDL--GLEQIAVSQMLLTQQ--PTSVDFEESMGAMHRLQTVYNLDSY 150
            |:::.|:.:|.:...|:.||:  |.    :|.:.:.:|  |...|...:..|:.|||..||||:.
Mouse    86 KLMKRLNTEWSELENLILKDMSDGF----ISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTN 146

  Fly   151 AMTEGFIDD-KDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYHYDDNVSPEVLKIKLWN 214
            .:::|.:.. :.|:.  .:|::|..||.:.....||..:|.|:|.||...::.....|.|:.:.:
Mouse   147 TISKGNLPGVQHKSF--LTAEDCFELGKVAYTEADYYHTELWMEQALTQLEEGELSTVDKVSVLD 209

  Fly   215 YPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPKLKHLQSNPA------------ 267
            |      |..|....|...:|.....:||.::|.|......|...:::.|...
Mouse   210 Y------LSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSD 268

  Fly   268 KLTKPKK---------VFQLQKEICS----KRYRRKSGVLVCRYVDW--TPFLKLAPLKMEELSM 317
            :.|.|||         ..|..:.:|.    |...|:...|.|||.|.  .|...|||.|.|:...
Mouse   269 QKTAPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWD 333

  Fly   318 KPYISIFYGFLGQKDIEVLKNVSRPKLQR----------IEHLSGNCSCKIGNLSTSLHDVVRKV 372
            ||.|..|:..:...:||::|::::|:|:|          :|.:....| |...||.....||.::
Mouse   334 KPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPVTGALETVHYRIS-KSAWLSGYEDPVVSRI 397

  Fly   373 NELILGITGFPLKGNQMLEVINYGIAGNYNP-------EEPKIHNK-------ANAFIFLSNAGK 423
            |..|..:||..:...:.|:|.|||:.|.|.|       :||....:       |....::|:...
Mouse   398 NMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSA 462

  Fly   424 GGEIVFPSRHLKVRPRKGSMLVWENL------KKSLIYHQCPILKGNMWVANKVLN 473
            ||..|||.....|.|:||:.:.|.||      ..|..:..||:|.||.||:||.|:
Mouse   463 GGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLH 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_730342.2	P4Ha_N	33..159	CDD:462433	29/133 (22%)
		TPR repeat	169..197	CDD:276809	10/27 (37%)
		TPR repeat	202..245	CDD:276809	9/42 (21%)
		PLN00052	311..>470	CDD:177683	55/188 (29%)
P4ha1	NP_035160.1	P4Ha_N	24..155	CDD:462433	30/134 (22%)
		TPR	205..238		8/38 (21%)
		P4Hc	345..518	CDD:214780	51/173 (29%)