DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and p4ha3

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	XP_031752143.1	Gene:	p4ha3 / 100495824	XenbaseID:	XB-GENE-962355	Length:	547	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	121/529 - (22%)
Similarity:	214/529 - (40%)	Gaps:	107/529 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EVVSAPESYDFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPR 83
            ::.|:..|...|:..|..|         :.:|..|.:...:.|..:||...:.:...::.....:
Frog    30 DMYSSMASIQQAVGMEGAL---------LQHLGQYLQQETQRLSDLRRFYEKVQASHQAGGPPVQ 85

  Fly    84 NLIYGYKVLRHLHNDW---------PQYFRLLKKDLGLEQIAVSQMLLTQQPTSVDFEESMGAMH 139
            :.|..|.:|:.|.::|         .:..:.||:  |.|:  |.|.|    |...|.|.:..|:.
Frog    86 DPILAYTLLKRLQSEWMNVVHSSEANENIQALKE--GYEK--VKQDL----PAPEDVEGAAKALM 142

  Fly   140 RLQTVYNLDSYAMTEGFI------DDK----DKNIRNWSADECLMLGLMYLFLKDYNQSENWLEL 194
            |||.||:|:...:..|..      |.|    ..::...|||:|..:|.:...::||..|..|||.
Frog   143 RLQDVYSLNVNGLARGMFQRSSSSDTKLLYNPPHLSIMSADDCFHIGKVAYDMEDYYHSIPWLEE 207

  Fly   195 ALYHY----------DDNVSPEVLKIKLWNYPNLLESLVEANKGLGHYFEAKKYANELLSINPNH 249
            |:..:          |:....|.|....::|..           .|:...|...:.|.|..:|::
Frog   208 AVSRFRGSYGNWRTEDEGSLEEALDYLAFSYYK-----------AGNISHALDLSRECLLYDPDN 261

  Fly   250 TYMLTQLPKLKH-LQSNPA--------KLTKPK----KVFQLQKEIC----SKRYRRKSGVLVCR 297
            ..:...:.|.:. |..:|.        ||.:|.    |...|.:.:|    |:....:...:.|.
Frog   262 GRLARNIAKYEQILYESPTADADAEEMKLQRPNVTHLKTRDLYEGLCQTLGSQPTSYEDPHMSCM 326

  Fly   298 Y-VDWTPFLKLAPLKMEELSMKPYISIFYGFLGQKDIEVLKNVSRPKLQRIEHLSGNCSC----- 356
            | .:..|:|.|.|:|.|.:|::|.:.:::.|:...:.|.:|.::.|.|.|....||....
Frog   327 YDTNSHPYLLLQPMKKEIVSLRPQVVLYHDFVSDLEAEKIKELASPWLHRSVVASGEKQAEAEYR 391

  Fly   357 --KIGNLSTSLHDVVRKVNELILGITGF----PLKGNQMLEVINYGIAGNYNP--------EEPK 407
              |...|..::|..|:.::..|..:||.    |..  :.|:|:||||.|:|.|        :.|.
Frog   392 ISKSAWLKDTIHPFVQNLDTRISAVTGLNAHPPYA--EYLQVVNYGIGGHYEPHFDHATSRKSPL 454

  Fly   408 IHNK-----ANAFIFLSNAGKGGEIVFPSRHLKVRPRKGSMLVWENLKKS------LIYHQCPIL 461
            ....     |...|:||:...||...|...:......|.:.:.|.||.::      .::..||::
Frog   455 YRTNTGNRLATFMIYLSHVDLGGSTAFVFANFSSPVVKNAAVFWWNLHRNGLGDEDTLHAGCPVI 519

  Fly   462 KGNMWVANK 470
            .|:.|||||
Frog   520 IGSKWVANK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	30/132 (23%)
		TPR repeat	169..197	CDD:276809	11/27 (41%)
		TPR repeat	202..245	CDD:276809	7/42 (17%)
		2OG-FeII_Oxy	<362..470	CDD:304390	33/130 (25%)
p4ha3	XP_031752143.1	P4Ha_N	35..>104	CDD:400573	14/77 (18%)
		TPR repeat	182..210	CDD:276809	11/27 (41%)
		TPR repeat	215..257	CDD:276809	8/52 (15%)
		P4Hc	359..531	CDD:214780	44/172 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000