DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4174 and p4ha1

DIOPT Version :9

Sequence 1:	NP_001034031.2	Gene:	CG4174 / 40023	FlyBaseID:	FBgn0036793	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	509	Identity:	132/509 - (25%)
Similarity:	222/509 - (43%)	Gaps:	86/509 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DFAISSESQLSLLKLKETHVNNLQSYKKVLKKHLQKIRRAIRQSEELLKSTKTSPRNL----IYG 88
            ||..|....:.||..::..|.:|:.|.|..::.|.:|::...:.:.|..:....|...    :..
Frog    19 DFFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTATKDPEGYLGHPVNA 83

  Fly    89 YKVLRHLHNDWPQYFRLLKKDL--GLEQIAVSQMLLTQQ--PTSVDFEESMGAMHRLQTVYNLDS 149
            :|:::.|:.:|.:...|:.||:  |.    :|.:.:.:|  |...|...:..|:.|||..||||:
Frog    84 FKLMKRLNTEWVKLENLILKDISDGF----ISNLTIQRQYFPNDEDQTGAAKALLRLQDTYNLDT 144

  Fly   150 YAMTEGFIDDKDKNIRNWSADECLMLGLMYLFLKDYNQSENWLELALYHYDDNVSPEVLKIKLWN 214
            ..:::|.:... |:..:.:|::|..||.......||..:|.|:|.||...|......:.|:.:.:
Frog   145 DTISKGNLPGV-KHKTSLTAEDCFDLGKTAYTDADYYHTELWMEQALSQLDAGEESSLDKVMVLD 208

  Fly   215 YPNLLESLVEANKGLGHYFEAKKYANELLSINPNHTYMLTQLPKLKHLQSNPAKLT--------- 270
            |      |..|....|...:|.......|.::|.|......|..:...:||.:..:
Frog   209 Y------LSYAVYQQGDLDKALTLTKRSLELDPEHQRGNGNLRHIMSKESNKSSSSPSEGAELRT 267

  Fly   271 ---KPKKVFQLQK--EIC--------SKRYRRKSGVLVCRYVDW--TPFLKLAPLKMEELSMKPY 320
               :||...:.:|  ::|        |:|.:|    |.|||.|.  .|.|.|:|.|.|:...||.
Frog   268 RKGRPKDHLEKEKYEKLCRGEGVKMTSRRQKR----LFCRYFDGKKDPLLILSPTKQEDEWDKPR 328

  Fly   321 ISIFYGFLGQKDIEVLKNVSRPKLQRIEHLSGNCSCKI-GNLSTSLH-------------DVVRK 371
            |..::..:..::|..:|.:::|:|:|     ...|..| |.|.|:.:             .||.:
Frog   329 IVRYHDIISDEEISKVKELAKPRLRR-----ATISNPITGVLETAQYRITKSAWLSGYEDPVVAR 388

  Fly   372 VNELILGITGFPLKGNQMLEVINYGIAGNYNPE-------EPKIHNK-------ANAFIFLSNAG 422
            :|..|.|:||..:...:.|:|.||||.|.|.|.       ||....|       |....::|:..
Frog   389 LNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDFLRKYEPDAFKKLGTGNRVATWLFYMSDVE 453

  Fly   423 KGGEIVFPSRHLKVRPRKGSMLVWENLKK------SLIYHQCPILKGNMWVANK 470
            .||..|||.....|.|:||:.:.|.||.:      |..:..||:|.||.||:||
Frog   454 AGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVGNKWVSNK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4174	NP_001034031.2	P4Ha_N	33..157	CDD:285528	30/131 (23%)
		TPR repeat	169..197	CDD:276809	10/27 (37%)
		TPR repeat	202..245	CDD:276809	7/42 (17%)
		2OG-FeII_Oxy	<362..470	CDD:304390	42/140 (30%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	17/90 (19%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	53/176 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100