Protein Alignment AstC-R1 and GRPR

DIOPT Version :10

• Sequence 1: NP_649040.2
• Gene: AstC-R1 / 40020
• FlyBaseID: FBgn0036790
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 102/406 - (25%)
• Similarity: 171/406 - (42%)
• Gaps: 80/406 - (19%)

  Fly    57 LYGTDLPTYQHCIATRNSFAD------------LFTV-VLYGFVCIIGLFGNTLVIYVVLRFSKM 108
            |...::..:.||..:.:| ||            |:.: .:||.:.:|||.||..:|.:......|
Human     8 LLNLEVDHFMHCNISSHS-ADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSM 71

  Fly   109 QTVTNIYILNLAVADECFLIGIPFLLYTMRICS-----------WRFGEFMCKAYMVSTSITSFT 162
            :.|.|::|.:||:.|...||          .|:           |.||...|| .:....:||..
Human    72 RNVPNLFISSLALGDLLLLI----------TCAPVDASRYLADRWLFGRIGCK-LIPFIQLTSVG 125

  Fly   163 SSIF-LLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPVILYASTVE-QEDGIN 225
            .|:| |..:|||||.|:..|:.......|....:.:|..|..|.:|.:|..:::.... .|:..|
Human   126 VSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTN 190

  Fly   226 ---YSC------NIMWPDAYKKHSGTTFILYTFFLGFATPLCFILSFYYLVIRKLRSVG---PKP 278
               .||      |.:.|   |.||..:|:::     :..||..|..:||.:.:.|....   |..
Human   191 QTFISCAPYPHSNELHP---KIHSMASFLVF-----YVIPLSIISVYYYFIAKNLIQSAYNLPVE 247

  Fly   279 GT-KSKEKRRAHRKVTRLVLTVISVYILCWLPHWISQVALIHS-NPAQRDLSRLEILIFLLLGAL 341
            |. ..|::..:.:::.:.||..:.::..||||:.:  :.|..| :.::.|.|.|..:..:....|
Human   248 GNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHV--IYLYRSYHYSEVDTSMLHFVTSICARLL 310

  Fly   342 VYSNSAVNPILYAFLSENFRKSFFKAFTCMNKQDINAQLQLEPSVFTKQGSKKRGGSKRLLTS-- 404
            .::||.|||.....||::|||.|.....|           .:|.:..:  |...|.|...:||
Human   311 AFTNSCVNPFALYLLSKSFRKQFNTQLLC-----------CQPGLIIR--SHSTGRSTTCMTSLK 362

  Fly   405 --NPQIPPLLPLNAGN 418
              ||.:.....:| ||
Human   363 STNPSVATFSLIN-GN 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R1	NP_649040.2	7tmA_AstC_insect	78..364	CDD:320222	83/313 (27%)
		TM helix 1	79..105	CDD:320222	8/26 (31%)
		TM helix 2	112..138	CDD:320222	7/25 (28%)
		TM helix 3	149..179	CDD:320222	13/30 (43%)
		TM helix 4	191..213	CDD:320222	5/21 (24%)
		TM helix 5	241..270	CDD:320222	6/28 (21%)
		TM helix 6	287..317	CDD:320222	6/29 (21%)
		TM helix 7	332..357	CDD:320222	6/24 (25%)
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	82/312 (26%)
		TM helix 1	42..68	CDD:320252	8/25 (32%)
		TM helix 2	75..101	CDD:320252	8/35 (23%)
		TM helix 3	113..143	CDD:320252	13/30 (43%)
		TM helix 4	155..175	CDD:320252	4/19 (21%)
		TM helix 5	207..232	CDD:320252	9/32 (28%)
		TM helix 6	257..287	CDD:320252	7/31 (23%)
		TM helix 7	301..326	CDD:320252	6/24 (25%)