DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R1 and Kiss1r

DIOPT Version :9

Sequence 1:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_444474.1	Gene:	Kiss1r / 114229	MGIID:	2148793	Length:	396	Species:	Mus musculus

Alignment Length:	330	Identity:	101/330 - (30%)
Similarity:	150/330 - (45%)	Gaps:	69/330 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VLYGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLI-GIPF--LLYTMRICSWR 143
            :.:..:.::||.||:|||||:.|...||||||.||.|||..|..||: .:||  |||.:.  :|.
Mouse    47 LFFATLMLLGLVGNSLVIYVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLP--AWV 109

  Fly   144 FGEFMCK--AYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAV 206
            .|:||||  .|:...|:.:..::  |..||.||:.....|:.:...||..:|..||...|..||.
Mouse   110 LGDFMCKFVNYIQQVSVQATCAT--LTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAA 172

  Fly   207 LMLPVILYASTVEQEDGINYSCNIMWPDAYKKHSGTTFILYTFFLGFATPLCFILSFYYLVIRKL 271
            :..||:   :......|....|:..:|....:.:   |.||.....:..||....:.|..::|.|
Mouse   173 VSAPVL---ALHRLSPGPRTYCSEAFPSRALERA---FALYNLLALYLLPLLATCACYGAMLRHL 231

  Fly   272 --RSVGPKP------GTKSKEKRRAHR-KVTRLVLTVISVYILCWLPHWISQVALIHSNPAQRDL 327
              .:|.|.|      |....::..|.| ||:|||..|:.::..||.|
Mouse   232 GRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGP------------------ 278

  Fly   328 SRLEILIFLLLGAL-----------------------VYSNSAVNPILYAFLSENFRKSFFKAFT 369
                |.:||:|.||                       .|||||:||:|||||..:||::|.:...
Mouse   279 ----IQLFLVLQALGPSGAWHPRSYAAYAVKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCP 339

  Fly   370 CMNKQ 374
            |..::
Mouse   340 CCRQR 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	100/316 (32%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	90/295 (31%)
Kiss1r	NP_444474.1	7tmA_KiSS1R	43..334	CDD:320223	99/318 (31%)
		TM helix 1	44..70	CDD:320223	9/22 (41%)
		TM helix 2	77..103	CDD:320223	13/25 (52%)
		TM helix 3	115..145	CDD:320223	9/31 (29%)
		TM helix 4	157..177	CDD:320223	6/19 (32%)
		TM helix 5	201..230	CDD:320223	6/31 (19%)
		TM helix 6	256..286	CDD:320223	14/51 (27%)
		TM helix 7	302..327	CDD:320223	11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839248
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840