DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and Gpr17

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001065245.1	Gene:	Gpr17 / 767613	RGDID:	1589785	Length:	339	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	85/318 - (26%)
Similarity:	148/318 - (46%)	Gaps:	53/318 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 CSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIAD-ECFLIGIP 199
            |.|..:|||..:              ||.|.:::.:...|..|..|:::::||:|| .|.|:...
  Rat    36 CFYLLDFILAFV--------------GNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPT 86

  Fly   200 FLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLV 264
            .|:|.....:||||...|:.......:..:.|..||..:||||::|:.||:.|.:.|.|..:.|.
  Rat    87 RLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLA 151

  Fly   265 SAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLVLGFATPLTFILV 329
            .||.|:...:.|.|:::...||| :|..|.|...:.:..:.|.     |.||.:.|..|....:.
  Rat   152 CAFLWIVVAVAMAPLLVSPQTVQ-TNHTVVCLQLYREKASHHA-----LASLAVAFTFPFITTVT 210

  Fly   330 FYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQVALI--------SSA 386
            .|.|:||.|.. ||    :.:|....|..:::..|::.::.|::|:.|.:...:        |.:
  Rat   211 CYLLIIRSLRQ-GP----RIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCS 270

  Fly   387 PQRCASRLELAVFLACG-----CLSYSNSAMNPILYAFLSDNFKKSFMKACT--CAAR 437
            .||.         ||.|     ||:..|.|::|::|.|:::.|:.:.   |.  |:.|
  Rat   271 AQRA---------LALGNRITSCLTSLNGALDPVMYFFVAEKFRHAL---CNLLCSKR 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	60/216 (28%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	74/268 (28%)
Gpr17	NP_001065245.1	7tmA_GPR17	32..308	CDD:320289	82/305 (27%)
		TM helix 1	34..58	CDD:320289	8/35 (23%)
		TM helix 2	67..88	CDD:320289	7/20 (35%)
		TM helix 3	105..127	CDD:320289	3/21 (14%)
		TM helix 4	150..166	CDD:320289	5/15 (33%)
		TM helix 5	190..213	CDD:320289	6/27 (22%)
		TM helix 6	234..256	CDD:320289	4/21 (19%)
		TM helix 7	276..301	CDD:320289	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000