DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and Cysltr2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001155884.1	Gene:	Cysltr2 / 70086	MGIID:	1917336	Length:	309	Species:	Mus musculus

Alignment Length:	312	Identity:	87/312 - (27%)
Similarity:	142/312 - (45%)	Gaps:	38/312 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GPDCSYS------YNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIAD 191
            |...|||      .|| .|....|:|.::...|..||...|||.::..|..|..|:::||||.:|
Mouse     5 GTPSSYSNRNCTIENF-KKEFYPIIYLIIFFWGALGNGFSIYVFLQTCKKSTSVNVFMLNLATSD 68

  Fly   192 ECFLIGIPFLL-YTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRY 255
            ..|:..:||.. |..:..||.||:..|:....|..:..:||..||.::|..|::|..||     :
Mouse    69 FLFISTLPFRADYYFRGSNWIFGDLACRVMSYSLYVNMYTSIYFLTVLSVVRFLATVHP-----F 128

  Fly   256 RTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGN------VSCNIEWPDTQNSHTDSTFILY 314
            |...|:.:.|  ||:...::.: .|:.:|.:...||.      :||....|....|......|
Mouse   129 RMFHVTSVRS--AWILCGIIWV-FIMASSALLLVNGQEEKDNIISCLELSPQKFKSLLIMNHI-- 188

  Fly   315 SLVLGFATPLTFILVFYCLVIR-----KLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLP 374
            ::.:||..|...:.|.|.|:||     ::...||       :.:|||....::..:..::.|:||
Mouse   189 AVAVGFLLPFLTLTVCYLLIIRILLKAEIPESGP-------RAAHRKALTTIVIAMITFLLCFLP 246

  Fly   375 -HWISQVALISSAPQRCASRLELAVFLACGCLSYSNSAMNPILYAFLSDNFK 425
             |.:..:.|::.....|...|..|..:.. .::.:||..||.||.|..:|||
Mouse   247 YHALRTLHLVTWDKDSCGDVLHKATVITL-TMAAANSCFNPFLYYFAGENFK 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	60/227 (26%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	71/267 (27%)
Cysltr2	NP_001155884.1	7tm_GPCRs	23..300	CDD:391938	80/293 (27%)
		TM helix 1	25..49	CDD:341315	8/23 (35%)
		TM helix 2	58..79	CDD:341315	9/20 (45%)
		TM helix 3	96..118	CDD:341315	5/21 (24%)
		TM helix 4	141..157	CDD:341315	2/16 (13%)
		TM helix 5	183..206	CDD:341315	5/24 (21%)
		TM helix 6	227..252	CDD:341315	6/24 (25%)
		TM helix 7	268..293	CDD:341315	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000