DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and SSTR4

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001043.2	Gene:	SSTR4 / 6754	HGNCID:	11333	Length:	388	Species:	Homo sapiens

Alignment Length:	367	Identity:	130/367 - (35%)
Similarity:	206/367 - (56%)	Gaps:	52/367 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNY 215
            :|||||::||.||.|||:|::|::||:|.||||:||||:|||.|::.:||:..:..:.:||||:.
Human    53 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSV 117

  Fly   216 MCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVI 280
            :|:|.:....:..|||...|.::|.|||:||.||:.:..||.|.|:||::...|:.|:|:.||:.
Human   118 LCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIA 182

  Fly   281 LFASTVQSSNGN-VSCNIEWPDTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPK 344
            :||.|..:..|. |:||::||....|   :.|::|:.:|||..|:..|.:.|.|::.|:..|..:
Human   183 IFADTRPARGGQAVACNLQWPHPAWS---AVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALR 244

  Fly   345 HKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLACGCLSYSN 409
            ...::::||.:|:|:|||.|:..::.||:|.::.|:..:      ..:.|:..|......|||:|
Human   245 AGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNL------FVTSLDATVNHVSLILSYAN 303

  Fly   410 SAMNPILYAFLSDNFKKSF-----MKACTCAARKDVNAQLQLENSFFPKFGKGRQSERLL----- 464
            |..|||||.||||||::.|     ::.|.            ||       |.|...|..|
Human   304 SCANPILYGFLSDNFRRFFQRVLCLRCCL------------LE-------GAGGAEEEPLDYYAT 349

  Fly   465 GGNGKGGA---------QRGALTKKKCLATRNNNAPMATTTT 497
            ....||||         |:.||..:    ......|:..|||
Human   350 ALKSKGGAGCMCPPLPCQQEALQPE----PGRKRIPLTRTTT 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	85/216 (39%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	96/255 (38%)
SSTR4	NP_001043.2	7tmA_SSTR4	48..322	CDD:320639	111/277 (40%)
		TM helix 1	49..75	CDD:320639	13/21 (62%)
		TM helix 2	82..108	CDD:320639	14/25 (56%)
		TM helix 3	119..149	CDD:320639	11/29 (38%)
		TM helix 4	161..183	CDD:320639	8/21 (38%)
		TM helix 5	208..237	CDD:320639	10/31 (32%)
		TM helix 6	252..282	CDD:320639	12/29 (41%)
		TM helix 7	290..315	CDD:320639	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2578
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20286
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8609
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3938
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.940