DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and SSTR3

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001042.1	Gene:	SSTR3 / 6753	HGNCID:	11332	Length:	418	Species:	Homo sapiens

Alignment Length:	401	Identity:	129/401 - (32%)
Similarity:	213/401 - (53%)	Gaps:	49/401 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 ILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGN 214
            ::|.:||::||.||:||||||:|.:...:|||:||||||:|||.|::|:|||.....:..||||:
Human    49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGS 113

  Fly   215 YMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPV 279
            .||:..|....|..|||...|.:||.|||:||.||..|.|:||..|::.|||..|:.|.:::|||
Human   114 LMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPV 178

  Fly   280 ILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPK 344
            ::|:..   ..|..:|:::||:...:.. :.||:|:..|||..||..|.:.|.|::.|:.:.|.:
Human   179 VVFSGV---PRGMSTCHMQWPEPAAAWR-AGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRR 239

  Fly   345 ---HKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQVA-LISSAPQRCASRLELAVFLACGCL 405
               ...:.::||.|:||::|:.|::.::.||:|.::..:. ::...|:..|.   ..::.....|
Human   240 VWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAF---FGLYFLVVAL 301

  Fly   406 SYSNSAMNPILYAFLSDNFKKSFMKACTCAARKDVNAQLQLENSFFPKFGKGRQSERLLGG---- 466
            .|:||..|||||.|||..||:.|.:.....:|: |.:|   |.:..|......:.|....|
Human   302 PYANSCANPILYGFLSYRFKQGFRRVLLRPSRR-VRSQ---EPTVGPPEKTEEEDEEEEDGEESR 362

  Fly   467 -NGKGGAQRGALTKKKCLATRNNNAPMATTTTTTTTTTGTDAVTCLQPP-------VHQVPAEIQ 523
             .|||....|.:::                 .|...|:|.:     :||       ...:|.|..
Human   363 EGGKGKEMNGRVSQ-----------------ITQPGTSGQE-----RPPSRVASKEQQLLPQEAS 405

  Fly   524 VGNPATVLVVN 534
            .|..::.:.::
Human   406 TGEKSSTMRIS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	88/218 (40%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	97/258 (38%)
SSTR3	NP_001042.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		7tm_4	55..>158	CDD:304433	54/102 (53%)
		7tm_1	61..313	CDD:278431	97/258 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..418		18/107 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2578
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8609
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3938
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.940