DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and SSTR2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001041.1	Gene:	SSTR2 / 6752	HGNCID:	11331	Length:	369	Species:	Homo sapiens

Alignment Length:	329	Identity:	138/329 - (41%)
Similarity:	205/329 - (62%)	Gaps:	18/329 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LDHRNRPTQQNGSH---YLEYDDDGPDCSYS--------YNFILKLITMILYALVCIIGLFGNTL 165
            :|..:.|.  ||||   .:.:|.:|...|.:        |:.....:...:|.:||||||.||||
Human     1 MDMADEPL--NGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTL 63

  Fly   166 VIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFT 230
            ||||::|::||:|:|||||||||||||.|::|:|||...:.:.:||||..:|:..|....|..||
Human    64 VIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFT 128

  Fly   231 SSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSC 295
            |...|.:||.|||:||.|||.|.::|.|..:|:::...|..|:|::||::::|....:..|..||
Human   129 SIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSC 193

  Fly   296 NIEWPDTQNS-HTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTK 359
            .|.||....: :|.  ||:|:.:|||..|||.|.:.|..:|.|:.:.|.:..|.::|:|.:|||:
Human   194 TINWPGESGAWYTG--FIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTR 256

  Fly   360 LVLTVISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLACGCLSYSNSAMNPILYAFLSDNF 424
            :|..|::.:||||||.:|..|:.:|.|.....:...:..|:.  .|:|:||..||||||||||||
Human   257 MVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVV--VLTYANSCANPILYAFLSDNF 319

  Fly   425 KKSF 428
            ||||
Human   320 KKSF 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	97/216 (45%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	108/255 (42%)
SSTR2	NP_001041.1	7tmA_SSTR2	44..323	CDD:320637	126/282 (45%)
		TM helix 1	45..71	CDD:320637	15/25 (60%)
		TM helix 2	78..104	CDD:320637	18/25 (72%)
		TM helix 3	115..145	CDD:320637	13/29 (45%)
		TM helix 4	157..179	CDD:320637	6/21 (29%)
		TM helix 5	205..234	CDD:320637	13/30 (43%)
		TM helix 6	249..279	CDD:320637	14/29 (48%)
		TM helix 7	291..316	CDD:320637	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159762
Domainoid	1	1.000	223	1.000	Domainoid score	I2578
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8609
orthoMCL	1	0.900	-	-		OOG6_107077
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3938
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.770