DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and SSTR1

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001040.1	Gene:	SSTR1 / 6751	HGNCID:	11330	Length:	391	Species:	Homo sapiens

Alignment Length:	415	Identity:	145/415 - (34%)
Similarity:	231/415 - (55%)	Gaps:	41/415 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PNGTTLHQLESVESESYPSI----NGTQNETMVTSVRPHLDHRNRPTQQNGSHYLEYDDDGPDCS 137
            ||||.    .|..|...||.    .|..:..........::...|...|||:.     .:|...:
Human     3 PNGTA----SSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTL-----SEGQGSA 58

  Fly   138 YSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLL 202
            ...:||        |::||::||.||::||||::|::||:|.|||||||||||||..::.:|||:
Human    59 ILISFI--------YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLV 115

  Fly   203 YTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAF 267
            .:..:.:||||..:|:..:...::..|||...|.::|.|||:||.|||.:.|||.|.|:|:|:..
Human   116 TSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLG 180

  Fly   268 AWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLVLGFATPLTFILVFYC 332
            .|:.|:|::||:::|:.|..:|:|.|:||:..|:........ |:||:.::||..|:..|.:.|.
Human   181 VWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVG-FVLYTFLMGFLLPVGAICLCYV 244

  Fly   333 LVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQVALISSAPQRCASRLELA 397
            |:|.|:..|..|...:::|||.||:|.:|:.|:..::.||:|.::.|:..: .|.|..|:..:|:
Human   245 LIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNV-FAEQDDATVSQLS 308

  Fly   398 VFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKACTCAARKDVNAQLQLENSFFPKFGKGR---- 458
            |.     |.|:||..|||||.|||||||:||.: ..|.:..|..|:..::  ::....|.|
Human   309 VI-----LGYANSCANPILYGFLSDNFKRSFQR-ILCLSWMDNAAEEPVD--YYATALKSRAYSV 365

  Fly   459 ---QSERLLGGNGKGGAQRGALTKK 480
               |.|.|..|   |..:.|..|.:
Human   366 EDFQPENLESG---GVFRNGTCTSR 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	88/215 (41%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	101/254 (40%)
SSTR1	NP_001040.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		12/50 (24%)
		7tmA_SSTR1	59..334	CDD:320636	117/289 (40%)
		TM helix 1	61..85	CDD:320636	13/31 (42%)
		TM helix 2	94..115	CDD:320636	14/20 (70%)
		TM helix 3	131..153	CDD:320636	4/21 (19%)
		TM helix 4	176..192	CDD:320636	5/15 (33%)
		TM helix 5	221..244	CDD:320636	7/23 (30%)
		TM helix 6	270..292	CDD:320636	6/21 (29%)
		TM helix 7	302..327	CDD:320636	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2578
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8609
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3938
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.940