DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and P2RY12

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_073625.1	Gene:	P2RY12 / 64805	HGNCID:	18124	Length:	342	Species:	Homo sapiens

Alignment Length:	323	Identity:	71/323 - (21%)
Similarity:	142/323 - (43%)	Gaps:	48/323 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 CSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTN--IYILNLAIADECFLIGI 198
            |:..|. |.:::..:||.::..:||..|.|.:.:   |.::::.:|  |::.|..|:|...::..
Human    17 CTRDYK-ITQVLFPLLYTVLFFVGLITNGLAMRI---FFQIRSKSNFIIFLKNTVISDLLMILTF 77

  Fly   199 PF-LLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSK 262
            || :|...::|..|...::|:...|....|.:.|..||.:::.|||.....|..:...:....:|
Human    78 PFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAK 142

  Fly   263 LVSAFAWMTSVLLMLPVILFASTVQSSNGNV-SCN-------IEWPDTQNSHTDSTFILYSLVLG 319
            ::|...|....||.||.::..:. |..:.|| .|:       :.|.:..|......|.:..|:
Human   143 ILSVVIWAFMFLLSLPNMILTNR-QPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLI-- 204

  Fly   320 FATPLTFILVFYCLVIRKLHT-------VGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWI 377
                   ::|.|.|:.::|:.       ||        |...:||...|..:|:.:..|::|...
Human   205 -------VIVCYTLITKELYRSYVRTRGVG--------KVPRKKVNVKVFIIIAVFFICFVPFHF 254

  Fly   378 SQVALISSAPQ---RCASRLELAVFL---ACGCLSYSNSAMNPILYAFLSDNFKKSFMKACTC 434
            :::....|..:   .|.:  |..:|.   :...|:..|:.::|.:|.||..:|:.|.:....|
Human   255 ARIPYTLSQTRDVFDCTA--ENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKC 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	51/233 (22%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	58/278 (21%)
P2RY12	NP_073625.1	7tmA_P2Y12	26..310	CDD:341326	67/306 (22%)
		TM helix 1	26..53	CDD:341326	7/29 (24%)
		TM helix 2	59..84	CDD:341326	7/24 (29%)
		TM helix 3	97..127	CDD:341326	9/29 (31%)
		TM helix 4	139..161	CDD:341326	7/21 (33%)
		TM helix 5	186..215	CDD:341326	7/37 (19%)
		TM helix 6	235..263	CDD:341326	4/27 (15%)
		TM helix 7	276..300	CDD:341326	5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910