DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and p2ry4

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001025633.1	Gene:	p2ry4 / 595021	XenbaseID:	XB-GENE-943446	Length:	543	Species:	Xenopus tropicalis

Alignment Length:	466	Identity:	102/466 - (21%)
Similarity:	183/466 - (39%)	Gaps:	115/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 INGTQNETMVTSVRPHLDHRNRPTQQNGSHYLEYDDDGPDCSYSYNFILKLITMILYALVCIIGL 160
            |..|.:.:::|::         |..:|.::..|     ..|.::..|.. |:..|.|:.|.::||
Frog     5 IMATLHPSLLTTL---------PLPKNLTNNTE-----DSCVFNEGFKF-LLLPISYSGVFMVGL 54

  Fly   161 FGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLL-YTMQVGNWPFGNYMCKAYMVST 224
            ..|...|::.:...:....|.:|:.|||::|..:::.:|.|: |.....|||||..:||......
Frog    55 PLNITAIWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADQNNWPFGVALCKIVRFLF 119

  Fly   225 SITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSS 289
            ....::|.:||..:|..||..|||||::.|......:.::.|..|::.:|.::|.::|.:.....
Frog   120 YANLYSSILFLTCISVHRYRGVCHPITTLRCMNAKHAHVICALVWLSVMLCLVPNLMFVTVSPKV 184

  Fly   290 NGNVSCNIEWPDTQNSHTD-STFILYSLVLGFATPLTFILVFYCLVIRKL--------HTVGPKH 345
            ||.:..:...|:..:.:.: ||.|:..|   |..|...|...|.|:.|:|        |...|.:
Frog   185 NGTICHDTTLPEEFDKYVEYSTGIMCLL---FGIPCLIIACCYGLMARELMKPLVNGNHQTLPSY 246

  Fly   346 KSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLACGC------ 404
                ||||    .|.::.|:.|:..|::|..|::....            .|..|...|
Frog   247 ----KKRS----IKTIVIVMIAFAICFMPFHITRTLYY------------YARLLGVNCYALNVI 291

  Fly   405 ---------LSYSNSAMNPILYAFLSDNFKKSFMKACTCAARKDVNAQLQLENSFFPKFGKGRQS 460
                     |:.:||.::||||...:|.:::..::.
Frog   292 NFTYKITRPLASANSCIDPILYFLANDRYRRRLIRT----------------------------- 327

  Fly   461 ERLLGGNGKGGAQRGALTKKKCLATRNNNAPMATTTTTTTTTTGTDAVTCLQPPVHQVPAEIQVG 525
                       .:|.::..::|:.|   |.|..........|||         |:..|.||....
Frog   328 -----------VRRSSVHHRRCMHT---NHPGPHPEPEPHMTTG---------PLPVVSAEETQS 369

  Fly   526 NPATVLVVNAE 536
            |...|...|.|
Frog   370 NGRMVRDENEE 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	60/225 (27%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	69/279 (25%)
p2ry4	NP_001025633.1	7tmA_P2Y4	40..320	CDD:320496	78/302 (26%)
		TM helix 1	40..67	CDD:320496	8/26 (31%)
		TM helix 2	74..99	CDD:320496	8/24 (33%)
		TM helix 3	112..142	CDD:320496	8/29 (28%)
		TM helix 4	154..176	CDD:320496	4/21 (19%)
		TM helix 5	201..230	CDD:320496	9/31 (29%)
		TM helix 6	245..275	CDD:320496	10/37 (27%)
		TM helix 7	292..317	CDD:320496	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910