DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and Ackr2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001263648.1	Gene:	Ackr2 / 59289	MGIID:	1891697	Length:	378	Species:	Mus musculus

Alignment Length:	340	Identity:	85/340 - (25%)
Similarity:	159/340 - (46%)	Gaps:	60/340 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 QNGSHYLEYD--DD------GPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQ 177
            :|.|...:||  ||      ..|...|:.   ::...::|:|:.::||.||.|::.|::..:..:
Mouse    16 ENSSSIYDYDYLDDMTILVCRKDEVLSFG---RVFLPVVYSLIFVLGLAGNLLLLVVLLHSAPRR 77

  Fly   178 TVTNIYILNLAIADECFLIGIPFLLYTMQVG-NWPFGNYMCKAYMVSTSITSFTSSIFLLIMSAD 241
            ....:|:||||:::..|::.:||  :.:.|. :|.||:::||......||..:....|:..||.|
Mouse    78 RTMELYLLNLAVSNLLFVVTMPF--WAISVAWHWVFGSFLCKVISTLYSINFYCGIFFITCMSLD 140

  Fly   242 RYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDTQNSH 306
            :|:.:.|.....|.:..|.:.|:....|:||:.:.:|.::|....|:.:|...|..::    ..|
Mouse   141 KYLEIVHAQPLHRPKAQFRNLLLIVMVWITSLAISVPEMVFVQIHQTLDGVWHCYADF----GGH 201

  Fly   307 TD--STFILYSL-VLGFATPLTFILVFY----CLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTV 364
            ..  ..::.:.| :|||..||..::.||    |:::| |...|       :.|:.|....||:
Mouse   202 ATIWKLYLRFQLNLLGFLLPLLAMIFFYSRIGCVLVR-LRPPG-------QGRALRMAAALVI-- 256

  Fly   365 ISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLAC-------------GCLSYSNSAMNPIL 416
              .:...|.|:.::..         ..|.|:|.||..|             ..|::|:....|:|
Mouse   257 --VFFMLWFPYNLTLF---------LHSLLDLHVFGNCEISHRLDYTLQVTESLAFSHCCFTPVL 310

  Fly   417 YAFLSDNFKKSFMKA 431
            |||.|..|:: ::||
Mouse   311 YAFCSHRFRR-YLKA 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	56/223 (25%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	65/275 (24%)
Ackr2	NP_001263648.1	7tm_GPCRs	46..322	CDD:391938	75/303 (25%)
		TM helix 1	48..72	CDD:341315	8/23 (35%)
		TM helix 2	81..102	CDD:341315	8/22 (36%)
		TM helix 3	117..139	CDD:341315	5/21 (24%)
		TM helix 4	162..178	CDD:341315	4/15 (27%)
		TM helix 5	207..230	CDD:341315	7/22 (32%)
		TM helix 6	245..270	CDD:341315	6/28 (21%)
		TM helix 7	290..315	CDD:341315	7/24 (29%)
		C-terminal cytoplasmic tail. /evidence=ECO:0000250	326..378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000