DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and PTAFR

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_000943.1	Gene:	PTAFR / 5724	HGNCID:	9582	Length:	342	Species:	Homo sapiens

Alignment Length:	416	Identity:	94/416 - (22%)
Similarity:	170/416 - (40%)	Gaps:	108/416 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 YDDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRF--SKMQTVTNIYILNLAIAD 191
            :|....|..:.|.     :..|:|:::.::|:..|..|::|..|.  .|......|:::||.:||
Human     4 HDSSHMDSEFRYT-----LFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMAD 63

  Fly   192 ECFLIGIP-FLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRY 255
            ..|||.:| :::|....|||....::|........|.::.|..||.:::.:|:.||..||.:.:.
Human    64 MLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQA 128

  Fly   256 RTPFVSKLVSAFAWM-----TSVLLMLPVILFASTVQSS--NGNVSCNIEWPDTQNSHTDS---T 310
            .|......:|...|:     .|..|:|.   ..:||..|  :|||:...|       |.:.   .
Human   129 NTRKRGISLSLVIWVAIVGAASYFLILD---STNTVPDSAGSGNVTRCFE-------HYEKGSVP 183

  Fly   311 FILYSLVLGFATPLTFILVFYC-LVIRKLHTVGP--KHKSKEKKRSHRKVTKLVLTVISAYIFCW 372
            .::..:.:.|:..|.|:::.:| |||.:...:.|  :.::.|.|   |:...:|.||::.:|.|:
Human   184 VLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVK---RRALWMVCTVLAVFIICF 245

  Fly   373 LPHWISQVALISSAPQRCA------SRLELAV---FLACGCLSYSNSAMNPILYAFLSDNFKKSF 428
            :||.:.|:      |...|      |:...|:   .....||..:|..::|::|.||:..|:|..
Human   246 VPHHVVQL------PWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHL 304

  Fly   429 MKACTCAARKDVNAQLQLENSFFPKFGKGRQSERLLGGNGKGGAQRGALTKKKCLATRNNNAPMA 493
            .:                      ||...|.|                   :||
Human   305 TE----------------------KFYSMRSS-------------------RKC----------- 317

  Fly   494 TTTTTTTTTTGTDAVTCLQPPVHQVP 519
               :..||.|.|:.|.    |.:|:|
Human   318 ---SRATTDTVTEVVV----PFNQIP 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	58/231 (25%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	69/279 (25%)
PTAFR	NP_000943.1	7tmA_PAFR	16..304	CDD:320275	77/311 (25%)
		TM helix 1	16..43	CDD:320275	6/31 (19%)
		TM helix 2	52..77	CDD:320275	9/24 (38%)
		TM helix 3	90..120	CDD:320275	7/29 (24%)
		TM helix 4	132..154	CDD:320275	3/21 (14%)
		TM helix 5	183..212	CDD:320275	7/28 (25%)
		TM helix 6	225..255	CDD:320275	11/38 (29%)
		TM helix 7	272..297	CDD:320275	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910