DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and CYSLTR2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001295394.1	Gene:	CYSLTR2 / 57105	HGNCID:	18274	Length:	346	Species:	Homo sapiens

Alignment Length:	297	Identity:	90/297 - (30%)
Similarity:	146/297 - (49%)	Gaps:	35/297 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 ILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLL-YTMQVGNWPFG 213
            |:|.::...|:.||.|.|||.::..|..|..|:::|||||:|..|:..:||.. |.::..||.||
Human    43 IVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFG 107

  Fly   214 NYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAF-----AWMTSV 273
            :..|:....|..:..::|..||.::|..|::|:.||     :|...|:.:.||:     .|   :
Human   108 DLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHP-----FRLLHVTSIRSAWILCGIIW---I 164

  Fly   274 LLMLPVILFASTVQSSNGNV-SC------NIEWPDTQNSHTDSTFILYSLVLGFATPLTFILVFY 331
            |:|...|:...:....||:| ||      .|....|.|        ..:||:|...|...:.:.|
Human   165 LIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMN--------YIALVVGCLLPFFTLSICY 221

  Fly   332 CLVIRKLHTVGPKHKSKEKKRSHRK-VTKLVLTVISAYIFCWLP-HWISQVALISSAPQRCASRL 394
            .|:||.|..|  :......:.|||| :|.:::|:| .:..|:|| |.:..|.|.:.....|..||
Human   222 LLIIRVLLKV--EVPESGLRVSHRKALTTIIITLI-IFFLCFLPYHTLRTVHLTTWKVGLCKDRL 283

  Fly   395 ELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKA 431
            ..|:.:.. .|:.:|:..||:||.|..:|||.....|
Human   284 HKALVITL-ALAAANACFNPLLYYFAGENFKDRLKSA 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	67/229 (29%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	80/269 (30%)
CYSLTR2	NP_001295394.1	7tmA_CysLTR2	39..316	CDD:320285	89/292 (30%)
		TM helix 1	41..65	CDD:320285	9/21 (43%)
		TM helix 2	74..95	CDD:320285	10/20 (50%)
		TM helix 3	112..134	CDD:320285	4/21 (19%)
		TM helix 4	157..173	CDD:320285	4/18 (22%)
		TM helix 5	199..222	CDD:320285	6/30 (20%)
		TM helix 6	246..268	CDD:320285	7/22 (32%)
		TM helix 7	284..309	CDD:320285	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910