DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and LTB4R2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001158164.1	Gene:	LTB4R2 / 56413	HGNCID:	19260	Length:	358	Species:	Homo sapiens

Alignment Length:	367	Identity:	79/367 - (21%)
Similarity:	141/367 - (38%)	Gaps:	74/367 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 LVCIIGLFGNTLVIYVV--MRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYM 216
            |..::||.||..|::.:  .|.::.:.:....:|:||:||...|:..|..:..:....||.|...
Human    29 LAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAG 93

  Fly   217 CKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVIL 281
            |||.....:::.:.|.:...::|..|.:||..|..:||.|:|.:::.:....|:.::||.:|..:
Human    94 CKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAV 158

  Fly   282 FASTVQSSNGNVSCNIEWPD--TQNSHTDSTFILYSLVL----GFATPLTFILVFYCLVIRKLHT 340
            :...             |.|  .|..|.........|.|    .|..|...:|..|.:.:.:|.
Human   159 YRHL-------------WRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLR- 209

  Fly   341 VGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHW---ISQVALISSAPQRCASRL---ELAVF 399
             |.:..|   .|...:|.:||..::.|:...|.|:.   :.|.....:.|:...::|   ..|..
Human   210 -GARWGS---GRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAAR 270

  Fly   400 LACGCLSYSNSAMNPILYAFLSDNFKKSFMKACTCAARKDVNAQLQLENSFFPKFGKGRQSERLL 464
            .....|::.:|::||:||.|.:                          ....|:.|. |...||.
Human   271 AGTTALAFFSSSVNPVLYVFTA--------------------------GDLLPRAGP-RFLTRLF 308

  Fly   465 GGNG--KGGAQRGALTKKKCLATRNNNAPMATTTTTTTTTTG 504
            .|:|  :||.             |:....|...||......|
Human   309 EGSGEARGGG-------------RSREGTMELRTTPQLKVVG 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	51/223 (23%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	59/268 (22%)
LTB4R2	NP_001158164.1	7tm_GPCRs	21..300	CDD:355774	66/314 (21%)
		TM helix 1	23..47	CDD:341315	6/17 (35%)
		TM helix 2	58..79	CDD:341315	7/20 (35%)
		TM helix 3	95..117	CDD:341315	3/21 (14%)
		TM helix 4	140..156	CDD:341315	3/15 (20%)
		TM helix 5	179..202	CDD:341315	5/22 (23%)
		TM helix 6	220..245	CDD:341315	6/24 (25%)
		TM helix 7	267..292	CDD:341315	8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..358		8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910