DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and Gpr34

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001020096.1	Gene:	Gpr34 / 554353	RGDID:	1563681	Length:	373	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	79/341 - (23%)
Similarity:	135/341 - (39%)	Gaps:	63/341 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 GSHYLEYDDDGPDCSYSYNF--------------ILKLITMILYALVCIIGLFGNTLVIYVVMRF 173
            |.|::..|.|    ..|.||              :|..:....|:::.|:||.||.:.:||.:..
  Rat    14 GMHFITNDSD----QVSQNFSGVSNVTSCPMDEKLLSTVLTTFYSVIFIVGLVGNIIALYVFLGI 74

  Fly   174 SKMQTVTNIYILNLAIADECFLIGIPF-LLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLI 237
            .:.:....||:||:|:||...:..:|| ::|.:....|..|..:||.......:..:.|.|.|..
  Rat    75 HRKRNSIQIYLLNVAVADLLLIFCLPFRIMYHINQNRWTLGVILCKVVGTLFYMNMYISIILLGF 139

  Fly   238 MSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDT 302
            :|.||||.:...|...|..|...|..|....|..::...|.:|:.  |::....|.:....:.|.
  Rat   140 ISLDRYIKINRSIQQRRAITTKQSVYVCCVVWTVALAGFLTMIIL--TLKKGGHNSTMCFHYRDK 202

  Fly   303 QNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRS-------HRKVTKL 360
            .|:..::.|       .||..:.|.|:| .|:|.....:|.......|:||       :....:.
  Rat   203 HNAKGEAIF-------NFALVVMFWLIF-LLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARN 259

  Fly   361 VLTVISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLACGC---------------LSYSNS 410
            ...|:..:..|::|:...:...|||.            ..|..|               ||..||
  Rat   260 SFIVLIIFTICFVPYHAFRFIYISSQ------------LNASSCYWKEIIHKTNEIMLVLSSFNS 312

  Fly   411 AMNPILYAFLSDNFKK 426
            .::|::|..:|.|.:|
  Rat   313 CLDPVMYFLMSSNIRK 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	54/223 (24%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	63/277 (23%)
Gpr34	NP_001020096.1	7tmA_GPR34-like	47..330	CDD:320276	71/304 (23%)
		TM helix 1	49..73	CDD:320276	8/23 (35%)
		TM helix 2	82..103	CDD:320276	9/20 (45%)
		TM helix 3	120..142	CDD:320276	4/21 (19%)
		TM helix 4	165..181	CDD:320276	3/15 (20%)
		TM helix 5	208..231	CDD:320276	8/30 (27%)
		TM helix 6	257..279	CDD:320276	3/21 (14%)
		TM helix 7	298..323	CDD:320276	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000