DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and GPR87

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_076404.3	Gene:	GPR87 / 53836	HGNCID:	4538	Length:	358	Species:	Homo sapiens

Alignment Length:	345	Identity:	78/345 - (22%)
Similarity:	151/345 - (43%)	Gaps:	45/345 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 SHYLEYDDDGPDCSYS-YNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNL 187
            ||......|||..:.: :|....::..:||.::.:..:..|.|.:::.... :.:|....|:.|:
Human    20 SHNSGNRSDGPGKNTTLHNEFDTIVLPVLYLIIFVASILLNGLAVWIFFHI-RNKTSFIFYLKNI 83

  Fly   188 AIADECFLIGIPF-LLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPIS 251
            .:||....:..|| :::....|.|.|...:|:...|......:||.:||.::|.|||:.|..|..
Human    84 VVADLIMTLTFPFRIVHDAGFGPWYFKFILCRYTSVLFYANMYTSIVFLGLISIDRYLKVVKPFG 148

  Fly   252 SPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCN-------IEWPDTQNSHTDS 309
            ..|..:...:|::|...|:...:|.||.|:..:...:.:....|:       ::|      ||..
Human   149 DSRMYSITFTKVLSVCVWVIMAVLSLPNIILTNGQPTEDNIHDCSKLKSPLGVKW------HTAV 207

  Fly   310 TFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSK-EKKRSHRKVTKLVLTVISAYIFCWL 373
            |::...|   |...|..::..|..:.|.:|....:..|: .:||.|.:..::|:.|   :..|:|
Human   208 TYVNSCL---FVAVLVILIGCYIAISRYIHKSSRQFISQSSRKRKHNQSIRVVVAV---FFTCFL 266

  Fly   374 PHWISQV--------ALISSAPQR----CASRLELAVFL-ACGCLSYSNSAMNPILYAFLSDNFK 425
            |:.:.::        .|:..:.|:    |.   |:.:|| ||      |..::||:|.|:..:|.
Human   267 PYHLCRIPFTFSHLDRLLDESAQKILYYCK---EITLFLSAC------NVCLDPIIYFFMCRSFS 322

  Fly   426 KSFMKACTCAARKDVNAQLQ 445
            :...|......|.:....||
Human   323 RRLFKKSNIRTRSESIRSLQ 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	49/224 (22%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	63/276 (23%)
GPR87	NP_076404.3	7tmA_GPR87	43..325	CDD:320635	68/303 (22%)
		TM helix 1	43..70	CDD:320635	4/26 (15%)
		TM helix 2	76..101	CDD:320635	6/24 (25%)
		TM helix 3	114..144	CDD:320635	10/29 (34%)
		TM helix 4	156..178	CDD:320635	6/21 (29%)
		TM helix 5	203..232	CDD:320635	8/37 (22%)
		TM helix 6	245..275	CDD:320635	8/32 (25%)
		TM helix 7	293..318	CDD:320635	11/33 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910